Amputee Coalition of America

McLEAN, Va., Sept. 18, 2024 (GLOBE NEWSWIRE) -- Thought Leadership & Innovation Foundation (TLI), a not-for-profit organization that works at the nexus of science, technology and public health, today announces the transfer of ownership of the Limb Loss and Preservation Registry (LLPR®) from the National Institute of Child Health and Human Development (NICHD) to TLI. This landmark decision, approved by NICHD, underscores TLI's commitment to driving transformative change in healthcare and validates the level of public confidence in TLI capabilities for assuming the management of this vital project. “Established in 2018 under an IDIQ Contract funded by the National Institutes of Health (NIH), the LLPR has been instrumental in measuring and reporting patient data to enhance limb loss and limb difference treatment as well as preservation efforts nationwide,” says Shawn Murphy, vice president, TLI and former program manager for LLPR under NICHD and Mayo Clinic. Murphy continues, “With this transfer of ownership, TLI is poised to further the LLPR's mission of improving the quality, safety, effectiveness and cost of limb loss and limb difference treatment and preservation. We are honored to steward the LLPR into this new chapter.” A centralized data warehouse, the LLPR plays a crucial role in addressing public health knowledge gaps, refining rehabilitation approaches and guiding the development of functional devices for people with limb loss and limb difference. As part of TLI, the Registry will maintain its multi-stakeholder model, fostering collaboration among care providers, care sites, payers, device manufacturers, suppliers and regulatory agencies. “This transition marks a significant step forward in our collective efforts to drive healthcare innovation and improve outcomes for individuals facing limb loss and limb difference,” says Cass Isidro, president, Amputee Coalition. “Together, we will continue to provide valuable resources and support to individuals who have limb loss and limb difference, empowering them to live life fully and ensuring that no on faces the challenges and complexities of their journeys alone.” To support the LLPR in its mission to improve outcomes for individuals living with limb loss and limb difference, please click here. Your contribution directly impacts the quality of care and functional outcomes for the LLPR community. About TLIThe Thought Leadership & Innovation Foundation (TLI) is a not-for-profit organization that works at the nexus of science, technology and public health, innovating for superior prevention, treatment and outcomes for those facing life-altering medical diagnoses. TLI helps patients across the country and around the world find better healthcare outcomes. Visit www.thoughtfoundation.org and follow us on LinkedIn. About The Amputee Coalition: The Leading Voice on Limb Loss and Limb DifferenceThe Amputee Coalition is the only national nonprofit that serves all individuals who experience limb loss or limb difference. We are dedicated to ensuring that no one faces limb loss alone. Our mission is to support, educate, and advocate for people impacted by limb loss and limb difference. We work to provide vital resources to people with limb loss and limb difference, as well as their families and caregivers. With these resources, they can recover, readjust, and live the life they most want to live. Learn more at www.amputee-coalition.org.

Scientists in Cincinnati and Japan identify a population of progenitor cells that strongly promote new blood vessel growth in ischemic limbs at risk of amputation from diabetes and other conditions CINCINNATI, Dec. 19, 2023 /PRNewswire/ -- Across the United States, about 2 million people are living with an amputation and another 185,000 amputations occur every year, according to the Amputee Coalition, a Washington, DC-based support group. About 54% of these lost limbs were caused by vascular disease, including diabetes and peripheral arterial disease (PAD). And as more people are diagnosed with diabetes, in the U.S. and worldwide, the number of amputations keeps rising. Continue Reading Graphical abstract illustrates how CD271+ progenitor cells derived from adipose tissue can prompt limb-preserving blood vessel growth. Source: Cincinnati Children's and Cell Reports Medicine. Now, experts at Cincinnati Children's in collaboration with colleagues from Kanazawa University in Japan, have uncovered a new way to prompt blood vessel growth that shows promise as a treatment for preventing ischemia-induced amputations. Their discoveries were based on achieving a deeper understanding about why two patients in a clinical trial in Japan walked away with fully recovered limbs that appeared destined for amputation. The study, published Dec. 19, 2023, and featured as the cover article for the journal Cell Reports Medicine, was led by first author Oto Inoue, MD, PhD, a cardiologist from Japan and a research fellow with Cincinnati Children's, and Juan Sanchez-Gurmaches, PhD, Division of Endocrinology. Their team reports that a specific subset of stem cells isolated from adipose tissue (fat) that also carry the cell surface marker CD271 outperformed all other similar cell types at inducing blood vessel formation. The study also details key molecular mechanisms involved in the process. The scientists confirmed these findings by transplanting this population of human stem cells into mice with limb ischemia. In every case, the treatment rescued limbs that otherwise would have required amputation. Then the team analyzed data from a clinical trial to provide initial evidence that such a cell transplant may have already worked in humans. In this case, people with foot ulcers were treated with a generalized mix of stem cells collected from the patients' own tissues. Of the small number of patients analyzed, the two patients with fully recovered limbs received high numbers of CD271-positive stem cells. Those results in combination with the highly consistent benefits found in the mouse testing, appear to justify further work to launch a formal clinical trial, the co-authors say. "Critical limb ischemia is one of the most severe outcomes for PAD and undertreated diabetes. This research shows hopeful results that this new subset of progenitors may have positive therapeutic value," Inoue says. "It was quite inspiring to see that one of the patients has recovered enough to return to work." A race to address a widespread health problem With rising rates of obesity plaguing the United States, diabetes incidence has been rising for years, and leading to a host of cardiovascular complications, including PAD leading to critical limb ischemia. Doctors treat PAD by using medications to slow the disease while performing bypass surgeries or catheter-based procedures to open clogged arteries in the limbs. However, many of the arteries that need treatment in the limbs are too small and difficult to access with surgery. As a result, at least a third of the people who need revascularization therapy are not eligible for surgical interventions. Those who lose their limbs go on to experience significant pain and disability while their underlying cardiovascular disease makes them increasingly likely to experience potentially fatal heart attacks, strokes, and other problems. Once seen as a purely adult health problem, researchers at Cincinnati Children's and other centers have been finding early signs of vascular disease in teens and even younger children who struggle with severe obesity and diabetes. Emerging alternatives from international collaboration Inoue, 40, has been studying PAD in Japan for more than a decade. He came to Cincinnati in 2021 to further study the emerging area of induced angiogenesis through cellular transplantation as a member of the Sanchez-Gurmaches lab. Many researchers have explored the idea of transplanting progenitor cells to jump-start the body's own tissue-repair capabilities. However, the major limitation has been finding the right cells to use. To solve this, the team used single-cell transcriptomics to hunt through a haystack of different types of progenitor cells to find the right population of cells. While many stem cells reside naturally in the bone marrow, this study found the strongest trigger of blood vessel formation lurking within fat tissue. These cells carry the marker CD271, which has been shown in other studies to play important roles in tissue growth. The team transplanted these human CD271-positive cells into mice to confirm their abilities. The human CD271 cells were 100% effective at prompting enough blood vessel growth in the mice to restore normal blood flow to the diseased limbs. Evidence that this new cell population may work in human disease also was provided. The authors found that among people who received progenitor cells self-transplanted from fat, those who recovered better and saved their limbs had higher numbers of CD271 progenitor cells present. "The positive correlation between recovery and the number of CD271+ progenitors injected in the affected area of these patients was striking," Sanchez-Gurmaches says. Challenges ahead The co-authors emphasize that the findings so far are preliminary. The therapeutic value of adipose tissue CD271-positive cells should be evaluated in larger numbers of patients through a formal clinical trial. One significant issue to resolve is how to obtain enough CD271 progenitor cells to use as treatment. The new paper reports that the number of CD271 progenitors found in the fat of people with insulin resistance can be as much as 75% lower than people without insulin resistance. Also, the cells that are found tend to be less active in generating new vessels. "Unfortunately, the people living with insulin resistance who face elevated risk of limb ischemia are the same people with low numbers of CD271-postive progenitor cells, which could make self-transplantation more difficult," Inoue says. More research is needed to determine if these cells can be multiplied in the lab before transplantation. About the study In addition to Inoue and Sanchez-Gurmaches, Cincinnati Children's co-authors included PhD student Manasi Halurkar, Hee-Woong Lim, PhD, and Vivian Hwa, PhD. Funding sources for this study include the National Institutes of Health (R21OD031907); the Japan Society for the Promotion of Science (JP16H06828); the Japanese Heart Foundation; the American Heart Association (18CDA34080527), and three grants from Cincinnati Children's (a Trustee Award, a Center for Pediatric Genomics Award and a Center for Mendelian Genomics & Therapeutics Award. SOURCE Cincinnati Children's Hospital Medical Center

Pune, India, Aug. 03, 2021 (GLOBE NEWSWIRE) -- The orthosis and prosthetics market is expected to reach USD 6,250.2 million in 2021 and is projected to grow at a CAGR of 4.8% during the forecast period. Prosthesis is an artificial limb or part of the body used to replace a missing, amputated, or underdeveloped body part. Orthosis is a device used to accommodate, correct, or enhance the use of a body part. Get Sample Copy of This Report @ Rising prevalence of osteosarcoma and increasing number of diabetes-related amputations has led to high demand for orthosis and prosthetics treatment in healthcare. Rising adoption of orthopedic technology in healthcare due to increasing cases of sports injuries, accidents, disabilities, and health conditions that result in movement restriction is driving the orthosis and prosthetics market growth. Prosthetic and orthotic devices provide patients mobility and stability. Studies have shown that prosthetic and orthotic rehabilitation improves the quality of life, health and offers functional, societal, and psychological support to the patients. For instance, the World Health Organization (WHO 2015-2017 work plan) estimated, about 1.5% of the world population may require prosthetic and orthotic interventions for their well-being. Also, only 5-15% (each 10th individual) of the population is in need has access to prosthetic and orthotic devices. According to the UN Development Program, 80% of people with disabilities live in developing countries. However, the government and international welfare agencies are working towards the inclusion of differently-abled in society by implementing disability acts, promoting awareness with support initiatives and increasing healthcare funding for orthosis and prosthetics. There is an increasing demand for prosthetics and orthotics treatment as it serves many functions for the elderly and disabled. This is expected to contribute to market growth during the forecast period. Some Significant Market Developments Considered in the Report: COVID-19 Impact on the Global Orthosis and Prosthetics Market The COVID-19 pandemic has placed enormous strain on healthcare services and assistive technology practitioners. There is an increasing need to promote health coverage and support to amputees and disabled patients. In addition, the growing emphasis on quality maintenance, assuring patient support and preventive initiatives regarding COVID-19 pandemic is expected to contribute to the orthosis and prosthetics market growth. Orthosis and Prosthetics Market, by Product Type Based on product type, the market is divided into orthosis and prosthetic. Among these segments, orthosis segment holds the largest market share in 2021 and is expected to remain the largest segment during the forecast period. Increasing incidences of sports injuries, rise in prevalence of osteoarthritis, and increasing adoption of orthopedic technology are expected to drive the segment growth. Increasing use of orthosis to support, align, prevent, or correct deformities or to improve the function of movable parts of the body is expected to fuel the segment growth. Orthosis and Prosthetics Market, by Age Group Based on age group, the market is divided into pediatric and adult. Among these segments, the adult segment is expected to be the fastest growing segment during the forecast period. The segment growth can be attributed to increasing geriatric population who are more prone to orthopedic injuries as compared to children. As a result, there is an increase in number of adults seeking treatment for orthosis and prosthetics. The orthosis and prosthetics devices are used for treating adults as adults have high adaptability to these devices and maturity to handle these supporting devices. Enquiry Before Buying This Report @ Orthosis and Prosthetics Market, by Indication Based on indication, the market is divided into lower limb deformities, upper limb deformities, and spinal. Among these segments, the lower limb deformities segment holds the largest market share in 2021 and is expected to remain largest during the forecast period. The segment growth can be attributed to injuries and accidents resulting in disability or genetic disability in lower leg. A lower limb orthosis is used to compensate or control decreased or abnormal forces in the hip, knee, ankle, or foot. Orthosis and Prosthetics Market, by Region Based on region, the orthosis and prosthetics market is segmented into North America, Europe, Asia-Pacific, Middle East and Africa, and South America. North American orthosis and prosthetics market holds the largest market share. The regional market growth can be attributed to increased focus on healthcare, the presence of key players with a strong distribution network, and well-established healthcare infrastructure. There is an increasing prevalence of limb amputation in the U.S. According to the Amputee Coalition (Limb Loss and Limb Difference Awareness Month of April 2021), more than 2 million Americans live with limb loss or limb difference, while 185,000 amputations are performed annually. Hence, there is high demand for orthosis and prosthetics due to increasing number of amputation cases in the region. Asia Pacific is expected to be the fastest growing market during the forecast period. The regional market is driven by a rise in the number of road accidents, increasing cases of diabetes-related amputations, and supportive government initiatives and activities to promote healthcare and rehabilitation. The Asian Prosthetic and Orthotics Meeting took place in November 2018 in Thailand for fostering cooperation between Asian countries and discussing the ongoing and emerging issues related to prosthetics and orthotics. Hence, such initiatives and increasing government support is expected to boost regional market growth during the forecast period. Some Major Findings of the Orthosis and Prosthetics Market Report Include: Browse key industry insights spread across 195 pages with 135 market data tables and 91 figures & charts from the report, “Orthosis and Prosthetics Market, by Product Type (Orthosis, Prosthetic), Age Group (Pediatric, Adult), Indication (Lower Limb Deformities, Upper Limb Deformities, Spinal), and Region (North America, Europe, Asia Pacific, Middle East and Africa, South America) — Market Size and Forecasting (2021 to 2030)” in depth analysis along with the table of contents (ToC). 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