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MechanismmAChRs antagonists |
Active Org.- |
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Active Indication- |
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Drug Highest PhasePending |
First Approval Ctry. / Loc.- |
First Approval Date- |
富马酸-(R,R)-戊乙奎醚注射液在健康志愿者中的单次给药安全性、耐受性及药代动力学研究
[Translation] A single-dose safety, tolerability and pharmacokinetics study of (R,R)-pentehyclidine fumarate injection in healthy volunteers
研究富马酸-(R,R)-戊乙奎醚注射液在中国健康志愿者中单次给药0.0625~2.0mg的安全耐受性; 研究富马酸-(R,R)-戊乙奎醚注射液单次给药药动学,并与戊乙奎醚消旋体进行药动学参数比较; 探明富马酸-(R,R)-戊乙奎醚注射液给药后在人体内是否发生构型转化。
[Translation] To study the safety and tolerability of a single dose of 0.0625-2.0 mg of (R,R)-pentehyclidine fumarate injection in healthy Chinese volunteers; To study the pharmacokinetics of a single dose of (R,R)-pentehyclidine fumarate injection and compare the pharmacokinetic parameters with those of the racemic penehyclidine fumarate injection; To determine whether configurational transformation of (R,R)-pentehyclidine fumarate injection occurs in the human body after administration.
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