Determination of median levels of the free β subunit of human chorionic gonadotropin in women from mainland China using a new time-resolved fluoroimmunoassay

Article

Author: Yin, Ai-Hua ; Yuan, Peng-Hui ; Xu, Wei-Wen ; Wu, Ying-Song ; Li, Ming ; Tang, Yong-Ping

AbstractBackground: The free β subunit of human chorionic gonadotropin (free β-hCG) is an important serum marker for biochemical screening. Its weekly median value varies with ethnicity. Most of the fluorometers for lanthanide chelates are designed for the detection of signals from europium (Eu3+) chelates only.Methods: We developed a two-site, one-step assay using two monoclonal antibodies (MAbs) against free β subunit and β subunit with Eu3+ chelates as labels. Using the present assay, we evaluated 24,634 normal serum samples in Chinese pregnant women during 8–20 weeks of gestation.Results: The detection limit using this assay was <0.05 ng/mL. The within-run and between-run imprecision was <6.0% and 7.0% using control material. Free β-hCG concentrations measured using the current assay in 999 maternal serum samples correlated well with those obtained by samarium (Sm3+)-labeled DELFIA free hCGβ assay (r=0.987). The medians for 8–20 weeks for maternal serum free β-hCG were higher in the women from mainland China compared to reports from other countries.Conclusions: The present assay is suitable for use in biochemical screening of women in mainland China. Our study on the median concentrations of free β-hCG will help establish reference values that are specific for ethnic populations from the Chinese mainland. These will be useful for studying the importance of ethnic factors in biochemical screening.Clin Chem Lab Med 2010;48:109–14.

Health Policy and Planning

Delivering integrated and standardized services to eliminate mother-to-child transmission of sexually transmitted infections: experience of the E-Clinic model in a Chinese pilot district

Article

Author: Lv, Dingyan ; Gao, Shuang ; Chen, Jiahong ; Luo, Yali ; Mai, Weizhen ; Wang, Wei ; Zhu, Yuanfang

AbstractThe elimination of mother-to-child transmission (EMTCT) of syphilis and hepatitis B virus (HBV) is a crucial strategy for preventing and reducing new pediatric infections. Timely and standardized EMTCT interventions for maternal infections have been demonstrated to be highly cost-effective and efficient. Regrettably, healthcare providers have encountered challenges in delivering these interventions due to the complexity of multidepartment referrals. Baoan district in Shenzhen, Guangdong Province, which serves as one of the six national pilot districts tasked with exploring effective EMTCT strategies, has pioneered the integration of infection management into antenatal care by establishing the E-Clinic (short for the Elimination of mother-to-child transmission Clinic) within the Obstetrics Department. The E-Clinic, through its provision of integrated services, has witnessed increased coverage of syphilis treatment for pregnant women living with syphilis, as well as increased coverage of antiviral treatment for high-risk pregnant women living with HBV. The E-Clinic has been recognized as a best practice for EMTCT by the World Health Organization and has been widely adopted and adapted in over 100 maternal and child healthcare institutions across Guangdong Province. The success of the E-Clinic underscores the importance of government leadership, innovation, and multilevel engagement in promoting standardized EMTCT services, providing insights for implementing EMTCT strategies in other regions worldwide.

100 Deals associated with Guangdong Women & Children's Hospital & Health Institute

100 Translational Medicine associated with Guangdong Women & Children's Hospital & Health Institute

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Guangdong Women & Children's Hospital & Health Institute

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