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Nervous System Diseases

Other Diseases

Small molecule drug

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Technology Platform

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Disease Domain	Count

Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

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COX x Opioid receptors	1

For pH < pKa₁ of chloroquine (I) [54-05-7], a pos. charge was induced in neutral liposomes by ionizations of the I mol. which reduced the electrophoretic mobility at pH 8-10.Addition of I to pos.- or neg.-charged liposomes (obtained by incorporation of stearylamine and dicetylphosphate resp.) increased and decreased resp. their electrophoretic mobility.Pos.-charged liposomes containing I were toxic to cultured mouse peritoneal macrophages, but neutral and neg.-charged ones were well tolerated, indicating that the latter 2 should be used in liposome-cell interaction studies.

12 Apr 2011·Journal of Pharmacy and Pharmacology

The equivalence of Oxytetracycline tablets B.P.

Article

Author: Jones, Trevor M ; Frier, Malcolm ; Risdall, Peter C

The bioavailability and dissolution of oxytetracycline [79-57-2] in tablet form varied with particle size, time and temperature of storage, and the source of the tablets.Tablets with particle sizes of 170 and 59 μm underwent 55.8 and 73.1% dissolution during 40 min at pH 5.1.Percentage dissolution in 40 min decreased from 68.9 to 40.3% after storing the tablets for 3 months at 20-5°.

12 Apr 2011·Journal of Pharmacy and PharmacologyQ3 · MEDICINE

Effects of various diuretic agents in the mouse

Q3 · MEDICINE

Article

Author: Sim, M F ; Hopcroft, R H

AbstractDiuretic effects of seven orally-acting diuretic agents have been examined in the mouse. The following compounds, examples of various types of orally active compound available, produced their characteristic diuretic effects: bendrofluazide, frusemide, ethacrynic acid, acetazolamide, triamterene, aminophylline and Su 15049A. The diuretic effects of the various agents were demonstrated under both water and saline-loading conditions. After allowing for differences in baseline sodium excretion, all diuretics except acetazolamide caused a further enhancement of sodium excretion after saline-loading compared with water-loading tests. The mouse possesses several advantages over the more commonly used rat since the range of diuretic responsiveness is greater. These results suggest that the mouse is a suitable species for diuretic testing.

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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