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ABSTRACTAim:A simple and sensitive analytical method was developed to estimate dalbavancin, anti-biotic drug in injectable formulations.Materials and Methods:Separation of analyte was attained on a Phenomenex Luna C18 column (250 mm × 4.6 mm × 5 μm particle size) using potassium dihydrogen orthophosphate pH 3.0 adjusted with orthophosphoric acid: acetonitrile: methanol (70:20:10 % v/v/v) as mobile phase pumped at 1.0 mL/min. A UV detector was used for effluent detection at a wavelength of 288 nm.Results:The retention time for Dalbavancin was determined to be 3.96 minutes. The drug exhibited linearity within the concentration range of 20–100 μg/mL. The accuracy of the method was considered satisfactory and the mean recovery percentage is found to be in the acceptable range of 98.74-101.02 %.Conclusion:The RP-HPLC method was successfully developed, validated as per ICH guidelines. The proposed method was simple, precise, sensitive, rapid, robust for the estimation of dalbavancin in injectable formulations.

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