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A case report of early diagnosis of asymptomatic hairy cell leukemia using flow cytometry
Author: Awoleye, Oreoluwa ; Davis, Amanda ; Tadros, James ; Vassiliou, Evros
Hairy Cell Leukemia is an infrequent leukemia that can be recognized both microscopically and flow cytometrically once the patient develops symptoms.We present a case where early diagnosis was achieved using flow cytometry long before the patient became symptomatic.This was achieved by focusing on a small percentage (0.9%) of total leukocytes that exhibited a higher side scatter and brighter CD19/CD20 than the remaining lymphocytes.A bone marrow aspirate three weeks later confirmed the presence of malignant B-cells.Shortly after, the patient presented splenomegaly and complained of fatigue.
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