The WSK extracted from tremella fuciformis has excellent moisturizing and film-forming abilities because of its special glucomannan macromol. structure.The results of IN VIVO experiments showed that 0.1% WSK can strengthen the skin barrier, reduce the production of inflammatory factors (IL-β, IL-6, IL-10 and TNF-a), increase the skin moisture value and reduce the TEWL.Finally the WSK played a role of moisturizing, anti-allergy and keeping skin health.