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Nervous System Diseases

Immune System Diseases

Hemic and Lymphatic Diseases

Small molecule drug

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Disease Domain	Count

Hemic and Lymphatic Diseases	1
Immune System Diseases	1
Nervous System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

PARP(Poly (ADP-Ribose) polymerase)	1

Scientific evidence sustains PM_2.5 particles' inhalation may generate harmful impacts on human beings' health; therefore, their monitoring in ambient air is of paramount relevance in terms of public health. Due to the limited number of fixed stations within the air quality monitoring networks, development of methodological frameworks to model ambient air PM_2.5 particles is primordial to providing additional information on PM_2.5 exposure and its trends. In this sense, this work aims to offer a global easily-applicable tool to estimate ambient air PM_2.5 as a function of meteorological conditions using a multivariate analysis. Daily PM_2.5 data measured by 84 fixed monitoring stations and meteorological data from ERA5 (ECMWF Reanalysis v5) reanalysis daily based data between 2000 and 2021 across the United Kingdom were attended to develop the suggested approach. Data from January 2017 to December 2020 were employed to build a mathematical expression that related the dependent variable (PM_2.5) to predictor ones (sea-level pressure, planetary boundary layer height, temperature, precipitation, wind direction and speed), while 2021 data tested the model. Evaluation indicators evidenced a good performance of model (maximum values of RMSE, MAE and MAPE: 1.80 µg/m³, 3.24 µg/m³, and 20.63%, respectively), compiling the current legislation's requirements for modelling ambient air PM_2.5 concentrations. A retrospective analysis of meteorological features allowed estimating ambient air PM_2.5 concentrations from 2000 to 2021. The highest PM_2.5 concentrations relapsed in the Mid- and Southlands, while Northlands sustained the lowest concentrations.

01 Feb 2025·Journal of Critical Care

Understanding ventilator-induced lung injury: The role of mechanical power

Review

Author: Liu, Kuan ; Parhar, Ken Kuljit S. ; Parhar, Ken Kuljit S ; Adhikari, Neill K.J. ; Kim, S. Joseph ; Urner, Martin ; Adhikari, Neill K J ; Fan, Eddy ; von Düring, Stephan ; Munshi, Laveena ; Kim, S Joseph

Mechanical ventilation stands as a life-saving intervention in the management of respiratory failure. However, it carries the risk of ventilator-induced lung injury. Despite the adoption of lung-protective ventilation strategies, including lower tidal volumes and pressure limitations, mortality rates remain high, leaving room for innovative approaches. The concept of mechanical power has emerged as a comprehensive metric encompassing key ventilator parameters associated with the genesis of ventilator-induced lung injury, including volume, pressure, flow, resistance, and respiratory rate. While numerous animal and human studies have linked mechanical power and ventilator-induced lung injury, its practical implementation at the bedside is hindered by calculation challenges, lack of equation consensus, and the absence of an optimal threshold. To overcome the constraints of measuring static respiratory parameters, dynamic mechanical power is proposed for all patients, regardless of their ventilation mode. However, establishing a causal relationship is crucial for its potential implementation, and requires further research. The objective of this review is to explore the role of mechanical power in ventilator-induced lung injury, its association with patient outcomes, and the challenges and potential benefits of implementing a ventilation strategy based on mechanical power.

01 Jan 2025·Methods in Molecular Biology

CRISPR-Mediated Construction of Gene-Knockout Mice for Investigating Antiviral Innate Immunity

Article

Author: Zheng, Chunfu ; Chen, Qi ; Zhao, Xiangqian ; Shen, Yangkun

With the rapid development of CRISPR-Cas9 technology, gene editing has become a powerful tool for studying gene function. Specifically, in the study of the mechanisms by which natural immune responses combat viral infections, gene knockout mouse models have provided an indispensable platform. This article describes a detailed protocol for constructing gene knockout mice using the CRISPR-Cas9 system. This field focuses on the design of single-guide RNAs (sgRNAs) targeting the antiviral immune gene cGAS, embryo microinjection, and screening and verification of gene editing outcomes. Furthermore, this study provides methods for using cGAS gene knockout mice to analyze the role of specific genes in natural immune responses. Through this protocol, researchers can efficiently generate specific gene knockout mouse models, which not only helps in understanding the functions of the immune system but also offers a powerful experimental tool for exploring the mechanisms of antiviral innate immunity.

100 Deals associated with University of Calgary Faculty of Law

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100 Translational Medicine associated with University of Calgary Faculty of Law

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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