Author: Knossow, Marcel ; Grosclaude, Jeanne ; Rezaei, Human ; Eghiaian, Frédéric ; Lesceu, Stéphanie ; Tréguer, Eric ; Debey, Pascale ; Doublet, Bénédicte

Prion diseases are associated with the conversion of the α-helix rich prion protein (PrP C ) into a β-structure-rich insoluble conformer (PrP Sc ) that is thought to be infectious. The mechanism for the PrP C → PrP Sc conversion and its relationship with the pathological effects of prion diseases are poorly understood, partly because of our limited knowledge of the structure of PrP Sc . In particular, the way in which mutations in the PRNP gene yield variants that confer different susceptibilities to disease needs to be clarified. We report here the 2.5-Å-resolution crystal structures of three scrapie-susceptibility ovine PrP variants complexed with an antibody that binds to PrP C and to PrP Sc ; they identify two important features of the PrP C → PrP Sc conversion. First, the epitope of the antibody mainly consists of the last two turns of ovine PrP second α-helix. We show that this is a structural invariant in the PrP C → PrP Sc conversion; taken together with biochemical data, this leads to a model of the conformational change in which the two PrP C C-terminal α-helices are conserved in PrP Sc , whereas secondary structure changes are located in the N-terminal α-helix. Second, comparison of the structures of scrapie-sensitivity variants defines local changes in distant parts of the protein that account for the observed differences of PrP C stability, resistant variants being destabilized compared with sensitive ones. Additive contributions of these sensitivity-modulating mutations to resistance suggest a possible causal relationship between scrapie resistance and lowered stability of the PrP protein.

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