Prostate cancer accounts for one third of nondermatologic cancers in men. Fortunately, early detection and technology have evolved to the point that an increasing number of men have more than one treatment option. These choices include prostatectomy, irradiation, hormone therapy, cryotherapy, and observation. However, each is associated with adverse effects and produces a different outlook. In this article, Dr Sweat explores these options and how they can be discussed with patients and tailored to meet their individual needs.