A review.Whole-cell biocatalysis has been exploited for thousands of years; for example, in preparing barley for beer brewing.While the chem., economic and social advantages of biocatalysis over traditional chem. approaches were recognized a long time ago, their applications for the drug industry have been largely underexplored until the recent technol. breakthroughs in large-scale DNA sequencing, robust protein expression systems, metabolic engineering and directed evolution.In this chapter, emphasis will be directed to the discussion of those isolated enzymes which are uniquely suited for the synthesis of small-mol. pharmaceutical ingredients.

High-performance polyurethane coatings and elastomers from C18-based polyols

Author: Brekin, Jonathan ; Wang, Zhe ; Bertin, Paul ; Beuhler, Allyson ; Tindall, Debra

This report highlights two polyurethane applications wherein incorporation of octadecanedioate (C18) polyols based on linear, long-chain aliphatic C18 diacid renders improvements in hydrolytic stability and mech. properties, while maintaining good processability.Polyurethane films constructed from conventional polyester polyol-derived PUDs are extremely sensitive to hydrolytic degradation, limiting their use to less demanding applications compared to polycarbonate-based systems.Herein, we disclose a novel class of C18 polyol-based PUDs that yield tough, flexible films with significantly lower processing viscosities yet competitive moisture resistance to traditional polycarbonate-based systems.Similar to PUDs, thermoplastic polyurethane (TPU) elastomers are used in a wide variety of applications exposed to extreme weathering conditions.For instance, in certain shoe sole applications, polyether-based TPUs are preferred for their excellent hydrolytic stability but often lack the desired mech. toughness, abrasion resistance, and tear strength.Herein, Elevance also describes how polyether polyols can be effectively blended with C18 polyols at different loadings to yield TPUs with improved mech. properties.Thus, C18 polyols likely represent a promising new class of high-performance building blocks for PUD coatings and elastomers capable of maintaining mech. properties upon exposure to moisture in demanding coating and TPU applications.

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