[Objective] Using polysaccharide content of Polygonatum sibiricum Red as a reference index, the effect of fresh Polygonatum sibiricum Red and Polygonatum sibiricum Red tablets by processing on the content of polysaccharide in Polygonatum from Rhizoma Polygonati was studied, so that a more reasonable processing technol. was selected for Polygonatum sibiricum Red.[Methods] The preliminary test uses different processing methods of fresh Polygonatum sibiricum Red and Polygonatum sibiricum Red tablets to obtain multiple groups of samples.Each sample was finely divided into powders.The content of Polygonatum sibiricum polysaccharides was determined by UV spectrophotometry, and the process most suitable for factory production was compared.Then select the steaming time, run time and stewing time as factors and each factor set three levels, the content of Polygonatum sibiricum polysaccharides was used as an index.The 3 factors and 3 levels orthogonal test was used to optimize the processing of Polygonatum sibiricum.Finally, the optimal processing technol. was used to verify the feasibility of the method.[Result] The main factors were the run time in the processing of the decoction pieces of wine.For the anal. of the extract, the factors that affect the content of the extract was steaming time, run time and stewing time, the steaming time was too long, the content of the extract was obviously decreased, which indicated that the steaming time should not be too long.For the anal. of Polygonatum sibiricum polysaccharides, effects of Polygonatum sibiricum polysaccharides content was run time, stewing time and steaming time, run time and stewing time longer, Polygonatum sibiricum polysaccharides content was high.[Conclusion] Polygonatum sibiricum polysaccharides content as the index, by comparison, polygonatum tablets plus 15% of rice wine run of 10 h, steamed 10 h, 10 h of stewing, taking out and drying, for Polygonatum optimum technol. conditions of production and good feasibility.