Thi Qar University

Materials science enhances the properties of metallic systems by combining components to create intermetallic compounds and alloys.Metallic alloy nanoclusters and doped metallic alloy nanoclusters hold potential applications in electronics, engineering, catalysis, and medicine.This study, examines three models of titanium-zirconium nanoclusters, denoted as Ti_nZr_n (n = number of atoms) were doped with two mols. of gallium-arsenic for each model.The constructed models include Ti₅Zr₄, Ti₄Zr₆, Ti₆Zr₉, Ti₅Zr₄Ga₂As₂, Ti₄Zr₆Ga₂As₂, and Ti₆Zr₉Ga₂As₂ utilizing Gaussian 09, DFT calculations, and B3PW-91 with LanL2DZ basis sets for each model.The study investigates the ionization potential (IP), electron affinity (EA), dipole moment (DM), mol. hardness (η), energy gap (Eg), softness (S), electronic charge (ΔNmax), binding energy (BE), IR and Raman activity of these nanoclusters.The results confirm the stability of nanoclusters.In conclusion, developing alloys that transition from nonconductive to semiconductive enhances it applications.The electronic devices including transistors, detectors, sensors, solar cells, integrated circuits and processors, optical devices, and high dielec. constant materials, which are particularly advantageous in manufacturing capacitors, as indicated by the values of energy gaps, DMs, and average polarizability.

The brain-derived neurotrophic factor (BDNF) is essential for neuronal health and function. Dysregulated BDNF levels have been correlated with the etiology of several neurological disorders, including Alzheimer's and Parkinson's diseases. Recently, biomarkers of central nervous system (CNS) inflammatory responses have been discovered in a variety of body fluids, including blood, cerebrospinal fluid (CSF), and tears. Personalized medicine and screening programs will become feasible once biosensing technologies advance sufficiently and are widely implemented in communities. This multidisciplinary review provides an overview of the molecular structure and synthesis of BDNF, emphasizing the complexity and intricate regulation of this crucial neurotrophic factor, as well as exploring the potential of BDNF as a biomarker for neurological conditions. It focuses on its role in disease progression and its utility in early disease detection using aptasensors and immunosensors. We also discuss the challenges associated with utilizing BDNF as a biomarker, such as its complex regulation and the need for sensitive and specific detection methods by electrochemical and optical transducers. Furthermore, we highlight the potential of biosensors to overcome these challenges by enabling real-time, non-invasive, and point-of-care (POC) monitoring of BDNF levels.

MicroRNAs (miRs) have emerged as pivotal regulators in the development and progression of colorectal cancer (CRC), and MicroRNA-206 (miR-206) has garnered attention as a potentially influential factor. However, the specific biological functions and complete mechanistic understanding of miR-206 in CRC remain largely uncharacterized. This study aims to bridge this research gap by providing a comprehensive analysis of miR-206's role in CRC. An exploration of the molecular mechanisms regulated by miR-206, its intricate interplay with target genes, and its significant impact on cellular processes highlights its potential utility as both a diagnostic marker and a therapeutic target. The significance of this research lies in potentially enabling the development of innovative therapeutic approaches, ultimately aiming to improve prognosis and survival rates in CRC patients by elucidating the functions of miR-206. Critical pathways, such as c-Met and PTEN/AKT, play crucial roles within the regulatory network of miR-206 in CRC and impact various cellular processes involved in CRC pathogenesis, metastasis, and treatment response. Understanding the complex interactions between miR-206 and key signaling pathways like c-Met and PTEN/AKT is crucial for understanding the underlying mechanisms driving CRC initiation and progression. This knowledge can inform the development of targeted therapeutic interventions, potentially leading to improved patient outcomes and advances in CRC management.