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Last update 08 May 2025

Daesun Distilling Co., Ltd.

Subsidiary Company|1930|South Korea

Last update 08 May 2025

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Translational Medicine

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100 Clinical Results associated with Daesun Distilling Co., Ltd.

0 Patents (Medical) associated with Daesun Distilling Co., Ltd.

Literatures (Medical) associated with Daesun Distilling Co., Ltd.

01 Jun 2014·Food Science and Biotechnology

Fermented sea tangle attenuates oxidative stress in individuals with a high level of γ-glutamyltransferase: A randomized, double-blind, and placebo-controlled clinical study

Author: Jung Il Kim ; Young Mi Kang ; Jae-Young Je ; Bae-Jin Lee ; Jae-Suk Choi ; Jae-Young Cha ; In Soon Choi ; Young-Mog Kim ; Byung-Hyouk Nam

A randomized, double-blind, placebo-controlled study of fermented sea tangle (FST) was conducted using 48 healthy volunteers with high levels of γ-glutamyltransferase (GGT).Participants (n=48) were divided into a placebo group and a FST group, which consumed FST (1.5 g/day) for 4 wk.Serum GGT, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determinedPlasma 8-isoprostane, 8-hydroxydeoxyguanosine (8-OHdG), and protein carbonyl contents, which indicate lipid peroxidation, DNA damage, and oxidation of protein, were determinedDecreased serum GGT was found in FST consumption group, compared to the placebo group [mean values (IU/L): 78.71±19.14 and 116.75±38.55, resp., p<0.001].Administration of FST significantly (p<0.05) decreased levels of serum AST [mean values (IU/L): 31.08±7.25 and 26.79±6.53 resp., p<0.001] and ALT [mean values (IU/L): 42.63±18.99 and 31.83±14.21, resp., p=0.001], compared to the placebo group, and significantly (p<0.05) decreased concentrations of plasma 8-isoprostane, 8-OHdG, and protein carbonyl levels.

30 Jun 2011·Fisheries and aquatic sciences

GABA-enriched Fermented Laminaria japonica Protects against Alcoholic Hepatotoxicity in Sprague-Dawley Rats

Author: Lee, Bae-Jin ; Cho, Young-Su ; Kim, Young-Mog ; Je, Jae-Young ; Kang, Young-Mi ; Cha, Jae-Young

The sea tangle, Laminaria japonica has long been used in Korea as a folk remedy to promote health.Gamma-amino butyric acid-enriched (5.56% of dry weight) sea tangle was obtained by fermentation with Lactobacillus brevis BJ-20 (FLJ).A suppressive effect of FLJ on carbon tetrachloride-induced hepatotoxicity has been shown previously.Alc. administration to Sprague-Dawley rats leads to hepatotoxicity, as demonstrated by heightened levels of hepatic marker enzymes as well as increases in both the number and volume of lipid droplets as fatty liver progresses.However, FLJ attenuated alc.-induced hepatotoxicity and the accumulation of lipid droplets following ethanol administration.Addnl., FLJ increased the activities and transcript levels of major alc.-metabolizing enzymes, such as alc. dehydrogenase and aldehyde dehydrogenase, and reduced blood concentrations of alc. and acetaldehyde.These data suggest that FLJ protects against alc.-induced hepatotoxicity and that FLJ could be used as an ingredient in functional foods to ameliorate the effects of excessive alc. consumption.

01 Aug 2010·Food Science and Biotechnology

Hepatoprotective effect of chicory (Chicorium intybus) root extract against orotic acid-induced fatty liver in rats

Author: Young-Su Cho ; Jae-Young Cha ; Chae-Kyu Park

Effect of chicory root extract (CRE) on the triglyceride metabolism in orotic acid (OA)-fed rats was investigated. Liver weights and hepatic triglyceride concentrations were markedly increased by OA-feeding rats. These results were attributed to the significant increase in the activity of hepatic phosphatidate phosphohydrolase (PAP), diacylglycerol acyltransferase (DGAT), and ratelimiting enzymes for triglyceride synthesis. Supplementation of CRE to OA did significantly reduced the hepatic triglyceride concentrations and DGAT activity without affecting PAP activity. Furthermore, OA treatment was significantly decreased plasma triglyceride (TG) and increased hepatic TG concentrations and reduced microsomal triglyceride transfer protein (MTP) activity without diminishing MTP mRNA expression in rats. However, hepatic TG concentration was significantly decreased and MTP activity was also reduced without diminishing MTP mRNA expression in rats fed simultaneous with OA and CRE diet. The hepatocytes in the OA-feeding rats contained numerous largely fat droplets, but CRE feeding prevented the OA-induced fat accumulation. Present study demonstrates that CRE reduces the liver TG accumulation by reduced DGAT and MTP activities without diminishing MTP mRNA expression by OA administration.

100 Deals associated with Daesun Distilling Co., Ltd.

100 Translational Medicine associated with Daesun Distilling Co., Ltd.

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Daesun Distilling Co., Ltd.

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