A simple, sensitive and accurate spectrophotometric method has been developed for determination of atorvastatin calcium in raw material and tablets, using UV derivativeThe solvent used was 50% methanol.ID236nm was selected as UV detection.All the calibration curve shows a linear relationship between the absorbance and concentration and coefficient correlation was found to be 0.9997.The regression of the curve was Y = 0.99561x + 0.2148,.RSD0.44% value is below 2.0 for repeatability precision which indicated that the method is highly precised.The percentage recovery value 99.82% indicates the accuracy of the method and absence of interference of the excipients present in the formulation.The developed method can be suitable for the anal. of atorvastatin in bulk and pharmaceutical formulation.

International Journal of Pharmaceutical Sciences and Research

Development and validation of a high performance liquid chromatography method for determination of cefixime trihydrate and its degraded products formed under stress condition of UV light

Author: Barakat, Izzeldin E. ; Adam, Elsadig H. K. ; Saeed, Ahmed E. M.

A simple, accurate, precise, and sensitive reverse phase high performance liquid chromatog. (RP-HPLC) method for the determination of cefixime trihydrate and its degraded products were developed and validated.Drug was resolved on a C₁₈ column (waters spherisorb 25 cm × 4.6 mm, 5 μm), utilizing mobile phase of sodium dihydrogen phosphate monohydrate (0.1M aqueous) pH adjusted to 2.5 with diluted orthophospharic acid (10% aqueous) and methanol in a ratio of 3:1 resp.Mobile phase was delivered at the flow rate of 1.0 mL/min.Ultra violet detection was carried out at 254 nm.Separation was completed within 9.75 min.Calibration curve was linear with correlation coefficient (r²) = 0.9996 over a concentration range 10-50 μg/mL.Recovery was between 98.84, 100.25 percentage.Method was found to be reproducible with relative standard deviation (RSD) for intra and interday precision of < 1.0 over the said concentration range.The method was successfully applied to the determination of the decomposed products of cefixime trihydrate, it can be very useful and an alternate to performing the stability studies.

Pharmacia Sinica

Stability study of ciprofloxacin hydrochloride under stress conditions using reverse phase-high performance liquid chromatography method

Author: Saeed, Ahmed E. M. ; El Mukhtar Abd Elaziz, Mohammed ; Adam, Elsadig H. K.

The present study describes behavior of ciprofloxacin hydrochloride (Cipro-HCl) which was investigated under different stress conditions of sun light, UV light at 254 nm, and some pharmaceutical excipients using HPLC.RP-HPLC method were modified that could sep. the drug from its degradation products formed under these stress conditions.Degradation was found to occur under sun light and thermal, were successfully resolved on a C₁₈ column (5S, ODS 25 cm × 4.6 mm, 5 μm), utilizing mobile phase of 0.025 M orthophospharic acid (adjusted to pH 3.0 with triethylamine) and acetonitrile in a ratio of 87:13 resp.Mobile phase was delivered at the flow rate of 1.5 mL/min.Ultra violet detection was carried out at 278 nm.The method was validated with respect to linearity, precision, accuracy, selectivity, specificity, and ruggedness.The method was specific to drug and also selective to degradation products.Some pharmaceutical excipients were found to decrease the reaction rate of sunlight and thermal decomposition of ciprofloxacin hydrochloride in aqueous media.Other pharmaceutical excipients were found to increase the reaction rate of ciprofloxacin hydrochloride sun and thermal decomposition

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