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Congenital Disorders

Endocrinology and Metabolic Disease

Digestive System Disorders

Small molecule drug

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Disease Domain	Count

Endocrinology and Metabolic Disease	1

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Small molecule drug	1

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PPAR(Peroxisome proliferator activated receptor)	1

A search for troponin in surf clam foot muscle was made.The muscle, however, seemed to lack troponin, judging from SDS-PAGE and immunoblotting of myofibril, native thin filament, and so-called troponin fraction in addition to their effects on Ca²⁺-sensitivity of Mg-ATPase activity.In contrast, a 160-kDa actin-binding protein was found, though its effects on Ca²⁺ regulation in muscle contraction are unknown.

01 Dec 1989·Experientia

Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues

Article

Author: Imanishi, T. ; Okabe, M. ; Iwata, C. ; Satake, M. ; Chiba, Y. ; Kohama, Y. ; Yamamoto, K. ; Mimura, T.

D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).

01 Jan 1987·NIPPON SUISAN GAKKAISHI

Induction of phenol-sulfate conjugating activity by exposure to phenols and duration of its induced activity in short-necked clam.

Author: Shigehito Hamada ; Yuji Oshima ; Chie Taguchi ; Kunio Kobayashi

The induction of phenol-sulfate conjugating activity was studied by exposure to some phenolic compounds and also the duration of its activity induced by PCP (I) in the midgut gland of short-necked clam Ruditapes philippinarum was studied.The inductivity of phenol-sulfate conjugating activity in short-necked clam among PCP, resorcinol, p-cresol, p-chlorophenol, p-nitrophenol, and phenol was compared; PCP was the most effective inducer, resulting in a 2.4-fold activity in the control clam during the 3-day exposure period to 0.1 ppm PCP.A subsequent experiment was performed to elucidate the effect of long-term exposure to sublethal PCP (0.1 ppm) for 5 wk on the phenol-sulfate conjugating activity in clams, feeding on a unicellular green alga Dunaliella species by dipping the clams in its growing seawater-medium (∼4 × 10⁴ cells/mL) for 2-3 h every other day, when the test PCP-water was replaced by a newly prepared one.The conjugating activity in the clam increased with the time of exposure to PCP and reached 42 nmol/min/g-tissue at the 5-wk period, corresponding to ∼7-fold with that in the control.When the clams which were exposed to 0.1 ppm PCP for 2 wk and then transferred to PCP-free seawater, its induced activity of 24 nmol/min/g-tissue decreased gradually, but it was still at a level of 1.5-fold with that in the control even after 3 wk, although the biol. half-life of PCP accumulated in the clam was only ∼1 h.

100 Deals associated with Nippon Suisan Co. Ltd.

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100 Translational Medicine associated with Nippon Suisan Co. Ltd.

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Pipeline

Pipeline Snapshot as of 03 Aug 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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