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Overview

In hydrophobic interaction chromatog. (HIC), many common causes of scale-up failure are inadvertently built into the process in the development stage.As with other adsorptive chromatog. methods, one of the most prevalent deficiencies is inadequate characterization of product retention conditions.Some deficiencies are peculiar to HIC, including the denaturation of labile proteins on excessively strong hydrophobic supports and product loss during sample application caused by inadequate characterization of sample solubilityThis article addresses gel selection and the development of sample-application conditions that avoid these problems.The authors use monoclonal antibodies as models to illustrate key points.

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