DermaTech Pty Ltd.

The goal of this clinical trial is to compare the 2 different prototype of cytoselectivecryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities. The main questions it aims to answer are:
* the tolerance of 2 prototypes of cyto-selective cryotherapy treatments
* the performance of 2 prototypes of cyto-selective cryotherapy treatments Participants will be treated for each spots with a definied prototype during 6 treatment visits.
Researchers will compare the tolerance and performance of the 3 prototypes.

CS5_7 study aim to evaluate the tolerance and to adjust the mode of administration of two conditions of cryotherapy treatment applied on the brown spots of the face and hands with 1 prototype (816-v1). A brown spot is defined as solar or senile lentigo and post-inflammatory hyperpigmentation (PIH).
The study will evaluate the following prototype :
• Prototypes from (816-v1 201) to (816-v1 290)

CS5_3 aims to evaluate the tolerance and to adjust the mode of administration of 4 different conditions of cryotherapy treatments applied on the brown spots of the face and hands with 3 prototypes. A brown spot is defined as solar or senile lentigo and post-inflammatory hyperpigmentation (PIH).
Each treatment corresponds to a combination of a specific sequence of a cryogenic spray and of a frequency of application.
The study will evaluate 3 prototypes :
Prototype 1 : SN from (816-v1 001) to (816-v1 100)
Prototype 2 : SN from (816-v1 101) to (816-v1 150)
Prototype 3 : SN from (816-v1 151) to (816-v1 200)
Prototypes will be applied on the face and hands according to specific frequencies of application.