Several recent studies have demonstrated the potential of using continuous countercurrent tangential chromatog. (CCTC) for the purification of monoclonal antibody products. CCTC operates with a flowing resin slurry, exploiting traditional approaches of countercurrent staging to achieve > 10-fold increases in productivity compared to traditional batch columns in a truly steady-state low pressure (<15 psi) unit operation that can be directly integrated into a fully continuous biomanufg. process. The featured data shows productivity and product quality outcomes from Protein A capture, as well as Anion exchange and Cation exchange polishing steps for purification of a com. mAb. Another unique aspect of CCTC is the ability to use small particle size resins with improved binding kinetics and better system productivity but without any increase in pressure. The data also features our strategy for integrating the unit operations into a single process train incorporating an integrated in-line sampling strategy as sponsored by FDA contract ($2.5 Million award, 2017). In addition we discuss the potential of this platform to enable efficient processing of sensitive biologics because of significantly reduced residence time (<10 min from binding to elution), as well as rapid in-line buffer adjustments of eluted product.