Xuanfei Baidu Decoction Alleviated Sepsis-Induced ALI by Modulating Gut Microbial Homeostasis and Promoting Inflammation Resolution: Bioinformatics and Experimental Study

Article

Author: Zhuo, Yuzhen ; Cui, Lihua ; Yang, Lei ; Cui, Lingzhi ; Zhang, Sijia ; Wang, Ximo ; Li, Caixia ; Zhang, Junxia ; Zhang, Shukun ; Li, Yuhong ; Zhang, Lanqiu

The Xuanfei Baidu Decoction (XFBD) has shown effective therapeutic potential for acute lung injury (ALI) induced by lipopolysaccharide and immunoglobin G immune complexes. Herein, the protective effects and mechanisms of XFBD were investigated in a sepsis-induced ALI mouse model along with its effects on gut microbiota. Notably, bioinformatics and molecular docking analyses revealed that XFBD components exhibited a strong binding affinity to G-protein-coupled receptor 18 (GPR18). In the murine ALI model-induced by cecal ligation and puncture (CLP)-XFBD markedly improved lung histopathology, reduced M1 macrophage polarization, and decreased pro-inflammatory cytokine levels in both lung tissues and MH-S macrophages. Furthermore, XFBD downregulated key inflammatory pathways, including nuclear factor (NF)-κB, phosphorylated-NF-κB, CCAAT/enhancer binding protein-δ, and the nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 3/Caspase-1/gasdermin D axis. Additionally, XFBD restored the CLP-induced disruption in gut microbiota balance, increasing the abundance of Prevotellaceae and Ruminococcaceae_UCG_014. Altogether, the findings of this study suggest that XFBD alleviates CLP-induced ALI by modulating gut microbial homeostasis and inhibiting associated inflammatory pathways, particularly via GPR18 activation, presenting the promising therapeutic potential of XFBD for treating sepsis-induced ALI.

01 Jun 2022·Russian Journal of Bioorganic Chemistry

Synthesis and Glycogen Phosphorylase Inhibitory Activity of the Conjugates of 5-Chloroindoledicarboxylic Acid and Diazepine Derivatives

Author: Shuai, Li ; Zhang, Liying ; Guo, Yachun ; Wang, Youde ; Zhiwei Yan ; Ma, Can

In this work, three novel amide derivatives with chloroindole as the core were synthesized through different exptl. schemes.Subsequently, biol. evaluation of these compounds as inhibitors of glycogen phosphorylase (GP) was described.The results showed that three compounds exhibited certain inhibitory activity against glycogen phosphorylase.Among which compound I showed the best inhibitory effect with the IC₅₀ of 2.52μM.Finally, aiming at further understanding the interaction between the newly designed mols. and glycogen enbox1 phosphorylase, the possible binding mode were explored based on mol. docking simulations.The results showed that all target compounds could bind to glycogen phosphorylase, and all ligand mols. were docked within the active pocket.

RSC Adv.

Metabolomics study on the cytotoxicity of graphene

Author: Qiu, Junqiang ; Liu, Shumin ; Jiao, Guozheng ; Xu, Hongying ; Li, Xin ; Zhang, Ning

Graphene has attracted enormous attention due to its unique and novel properties, showing great potential in different fields including biomedical engineering, tissue engineering, and biosensors.

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