100 Clinical Results associated with Pennsylvania Drug Discovery Institute
0 Patents (Medical) associated with Pennsylvania Drug Discovery Institute
01 Nov 2018·Technology Transfer and Entrepreneurship
Analysis of the Market, Regulatory Landscape, and Current State of Clinical Trials Pertaining to Digital Health
Author: Carpenter, Marco D. ; Babiash, Eric S. ; Lee, Isabelle G. ; Blank, Patrick N. ; Li, Robin B. ; Allenby, Cheyenne E. ; Zhu, Yue ; Robustelli, Jaclyn ; Gross, Dennis M.
01 Nov 2018·Technology Transfer and Entrepreneurship
Preface: The Future of Medicine is Now
Author: Beyer, Chad E. ; Gross, Dennis M.
28 Mar 2015·Current Topics in Medicinal ChemistryQ4 · MEDICINE
Inhibitors of Leucine-Rich Repeat Kinase 2 (LRRK2): Progress and Promise for the Treatment of Parkinson’s Disease
Q4 · MEDICINE
Review
Author: Gilligan, Paul J
Mutations in the gene for leucine-rich repeat kinase 2 (LRRK2) have been linked to several familial and sporadic late-onset cases of Parkinson's disease. The cumulative data for the effects of mutant forms of this enzyme on neuronal degradation and the pathophysiology of Parkinson's disease create a compelling case for drug discovery based on inhibition of the mutant forms of LRRK2. This review focuses on structure-activity relationships for inhibitors of LRRK2 and the data supporting a potential role of these agents in treating Parkinson's disease.
100 Deals associated with Pennsylvania Drug Discovery Institute
100 Translational Medicine associated with Pennsylvania Drug Discovery Institute