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Overview

The level of reproducibility for sets of preparative liquid chromatography (prep-LC) columns was studied using a self-packing axial compression system. Standard deviations of less than 5% of the mean of the column efficiency and less than 2% of the mean of the retention time are reported for three sets of packed, prep-LC columns.

BioPharm (Duluth, MN, United States)

Process purification of polypeptides and proteins by reversed-phase column chromatography: Misconceptions and reality

Author: Harrison, Kervin ; Li, Michael ; Chadwick, Paul ; Lu, Philip ; Carr, C. David

A review and discussion.Whereas many companies use process-scale reversed-phase chromatog. for purifications, misconceptions about denaturation and cost have kept others from using this efficient purification tool.The authors address many of the misconceptions surrounding process use of reversed-phase separationsTheir goal is to show that RP-HPLC should take its place among the practical tools that process development scientists use to develop robust, cost-effective purifications for biopharmaceuticals.Several biopharmaceuticals currently on the market or in the pipeline benefit from reversed-phase processes.

Chromatographia

MODcol Expands Media Selection

Author: Anonymous

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