Jiangsu Sheneryang High-Tech Co., Ltd.

Evaluation of the safety and efficacy of succinate-containing octahydroacrylamide tablets in the treatment of mild to moderate Alzheimer's disease.

Primary objectives: (1) To evaluate the pharmacokinetic characteristics of succinic acid tablets when used alone and in combination with fluvoxamine in healthy adult Chinese subjects; (2) To evaluate the pharmacokinetic characteristics of succinic acid tablets when used alone and in combination with rifampicin in healthy adult Chinese subjects. Secondary objectives: (1) To evaluate the safety and tolerability characteristics of succinic acid tablets when used alone and in combination with fluvoxamine in healthy adult Chinese subjects; (2) To evaluate the safety and tolerability characteristics of succinic acid tablets when used alone and in combination with rifampicin in healthy adult Chinese subjects.

Primary objective: To evaluate the material balance and biotransformation pathway of [14C] succinic acid octahydrogenacridine after a single oral administration in healthy Chinese male volunteers. Secondary objective: To evaluate the overall pharmacokinetic characteristics and safety of succinic acid octahydrogenacridine in humans.