Xiamen Yangshengtang Biotechnology Co., Ltd.

Primary objective: To describe the occurrence of potential immune-mediated diseases and pregnancy outcomes in women aged 9-45 years during the pre-marketing and post-marketing observation period of Xinkening. Secondary objectives: 1) To describe the occurrence of other serious diseases in women aged 9-45 years, including primary ovarian failure, facial palsy, complex regional pain syndrome, and postural orthostatic tachycardia syndrome, during the pre-marketing and post-marketing observation period of Xinkening; 2) To describe the occurrence of potential immune-mediated diseases and other serious diseases in special populations of women aged 9-45 years (including HIV-infected people, malnourished adolescents, people at high risk of malaria exposure, and tuberculosis) during the pre-marketing and post-marketing observation period of Xinkening. Exploratory objectives: 1) To compare the differences in the occurrence of potential immune-mediated diseases and pregnancy outcomes in women aged 9-45 years who were not vaccinated and vaccinated with Xinkening.

To evaluate the long-term protection and immune persistence of a bivalent human papillomavirus vaccine (Escherichia coli) in women aged 18-45 years.

To evaluate the long-term protection and immune durability of a bivalent human papillomavirus vaccine (Escherichia coli) in females aged 18-45 years.