Trans Genic Group, Inc.

– PRTX007 program to support DTRA’s efforts to establish biological defense solution against Lassa fever and other hemorrhagic viruses – SAN DIEGO--(BUSINESS WIRE)-- Primmune Therapeutics, a biotech company harnessing the power of the innate immune system, today announced that it was awarded a $22,480,552 contract by the United States Defense Threat Reduction Agency (DTRA) to develop PRTX007 as an oral broad spectrum antiviral TLR7 agonist for the treatment of Lassa fever. PRTX007 is a clinical-stage novel oral small molecule that specifically activates toll-like receptor 7 (TLR7), which drives the innate immune system’s primary response to viral infections, enabling broad spectrum antiviral activity. The objective of the program is to evaluate the efficacy of PRTX007 in a series of animal models for Lassa fever and establish an effective treatment method of Lassa virus in humans. In addition, the program will support the development of US-based manufacturing capabilities. “The scientific community has long recognized the therapeutic potential of systemically acting toll-like receptor agonists in the treatment of acute and chronic viral diseases, precancerous lesions and solid tumors,” said James Appleman, Ph.D., Co-founder and Chief Scientific Officer at Primmune Therapeutics. “PRTX007 is unique in that administration engages a coordinated innate and adaptive immune response which is required for therapeutic benefit, while avoiding excessive systemic inflammation – historically, a challenge associated with TLR7 agonists.” Primmune’s PRTX007 program will support DTRA’s efforts to counter current threats and challenges from Lassa fever and other hemorrhagic viruses through the development of a timely and effective biological defense solution. Primmune and DTRA expect the program to be completed by June 30, 2026. “Primmune has demonstrated broad spectrum antiviral activity with PRTX007 and with related compounds from our discovery and development program,” said Charlie McDermott, President, Chief Executive Officer and Director of Primmune Therapeutics. “PRTX007 has been shown to be amenable to scale-up, long-term storage and tableting, with the potential to be deployed as a single agent or in combination with direct antiviral compounds or other therapeutic modalities – underscoring its potential utility as a first line of defense against future novel pathogens in real-world settings.” Research and development funds in the amount of $845,610.00 were initially provided to Primmune on January 30, 2024. The contract agreement includes committed funding of $10.6 million, which will be provided to Primmune across a 14-month base period, with the potential to receive option period funding in the amount of $11.9 million, pending the achievement of performance milestones throughout the base period. “Treating African hemorrhagic fever viruses such as Lassa fever, Marburg virus disease and Ebola virus disease poses many challenges due to the underlying pathophysiology of the diseases and their highly infectious nature,” said Curtis Scribner, M.D., Chief Medical Officer at Primmune Therapeutics. “PRTX007’s novel immunologic approach has the potential for combination use with direct acting anti-viral agents – enabling widely applicable utility in the treatment of Lassa fever and other hemorrhagic viruses.” About PRTX007 PRTX007 is Primmune’s lead clinical development candidate. In a 130 person healthy volunteer SAD/MAD clinical study, PRTX007 was well-tolerated while also driving controlled, long-term systemic stimulation of the innate immune response. PRTX007 administration uniquely activates selected plasmacytoid dendritic cells (pDCs) functions, leading to a systemic immune poly-IFN response without stimulating production of NF-κB-driven proinflammatory factors like IL-6, TNFα or IL-1β. These activated pDCs directly deliver interferons to target cells by paracrine transfer. Conceptually, this is equivalent to administering a therapeutically effective cocktail of all Type I/III IFNs while avoiding the associated side effects and adverse events. Furthermore, repeated PRTX007 administration leads to pDC-mediated systemic activation of CD8+ T cells and NK cells, both of which are important for treatment of viral diseases and cancer. About Primmune Therapeutics Primmune Therapeutics is a clinical-stage biotech harnessing the power of the innate immune system for therapeutic benefit through development of novel small molecule, orally administered toll-like receptor 7 (TLR7) agonists. For more information, please visit .

CHICAGO, July 21, 2023 /PRNewswire/ -- In the near future, the humanized mouse and rat model industry is set to undergo transformative advancements, revolutionizing biomedical research and drug development. These cutting-edge models, where mice and rats are genetically modified to possess human-like characteristics and immune systems, will play a pivotal role in bridging the gap between preclinical studies and clinical trials. Through refined genetic engineering techniques, these models will closely mimic human physiology, enabling more accurate and predictive assessments of drug safety, efficacy, and disease mechanisms. Moreover, the industry will witness the integration of advanced technologies, such as CRISPR/Cas9, to expedite the creation of customized humanized models, tailoring them to specific diseases or individual patient profiles. These advancements will spur collaboration between academia, pharmaceutical companies, and biotech firms, fostering a dynamic research ecosystem focused on targeted therapies and personalized medicine. Ultimately, the humanized mouse and rat model industry will emerge as a key driver in medical breakthroughs, enhancing our understanding of complex diseases and paving the way for transformative healthcare solutions. Humanized Mouse and Rat Model Market in terms of revenue was estimated to be worth $259 million in 2023 and is poised to reach $349 million by 2028, growing at a CAGR of 6.2% from 2023 to 2028 according to a new report by MarketsandMarkets™. Rising demand for personalized medicine is one of the prominent driving factor of the humanized mouse and rat model market. Existing mouse models have certain limitations in predictive research, unable to effectively gauge response in human cancer patients. Therefore, research institutes and academic institutes are focused on the development of advanced innovative models. Demand for personalized medicine is further driven by advancements in proteomics, genomics, and metabolomics. Additionally demand for targeted diagnostics and preventive medicine are propelling the demand for humanized mouse and rat research models. Download an Illustrative overview: Browse in-depth TOC on "Humanized Mouse and Rat Model Market" 140 - Tables 27 - Figures 188 - Pages Humanized Mouse and Rat Model Market Scope: The genetic models dominated the humanized mouse and rat model market in 2022. Based on type, the humanized mouse and rat model market has been segmented into humanized mouse models and humanized rat models. The humanized mouse models segment is further divided into genetic humanized mouse models and cell-based humanized mouse models. The genetic models generated highest revenue in 2022. In genetic humanized mouse models, the human protein/domain is expressed while the mouse protein/domain is suppressed in all cells and tissues. Genetic humanized mouse models have been successfully adopted in analyzing biological efficacy, safety testing, pharmaceutical compounds, and studying novel therapeutics. Humanized mouse models are gaining demand in studies around drug metabolism and immune system development & functioning. The oncology segment represented a dominant share in the market in 2022. Based on application, the humanized mouse and rat model market is segmented into toxicology, oncology, immunology and infectious diseases, hematopoiesis, neuroscience, and other applications. Humanized models mimic human cancers and act as essential platforms for cancer research. Cancer research involves studying cancer biology and understanding or predicting cancer, including tumor characterization, tumorigenesis, and metastasis. The growth of this segment can be attributed to the growing number of cancer research programs in academic & research institutes and favorable support by governments for cancer research. The Asia Pacific region is the fastest-growing region of the humanized mouse and rat model market throughout the forecast period. Based on the region, the humanized mouse and rat model market is segmented into five major regions: North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. The Asia Pacific market is estimated to register the highest growth during the forecast period. Increase in demand for market products across China and India is the key contributive factor. Led by growing R&D activities, the outsourcing of preclinical, clinical, and laboratory testing services for small & large molecules is expected to increase in the country. The growing pharmaceutical industry, the rising number of CROs, and rising research activities will drive the growth of China's humanized mouse and rat model market. Request Sample Pages: Humanized Mouse and Rat Model Market Dynamics: Drivers: Increasing research activities using humanized models Rising demand for personalized medicine Continuous support and initiatives from government and private sectors for cancer research Growing R&D activities in pharmaceutical and biotechnology sectors Restraints: High cost of custom humanized models Laws and regulations for ethical use of animal models in research Opportunities: Rising demand for humanized PDX models Emergence of CRISPR as a powerful tool in biomedical research Rising demand for humanized rat models Challenges: Alternatives for animal testing Limitations of humanized mouse models Key Market Players: The prominent players in the global humanized mouse and rat model market include Charles River Laboratories (US), THE JACKSON LABORATORY (JAX) (US), Taconic Biosciences, Inc. (US), Crown Biosciences (US), Champions Oncology, Inc. (US), Hera BioLabs (US), genOway (France), Inotiv (US), Vitalstar Biotechnology (China), Ingenious Targeting Laboratory (US), TRANS GENIC (Japan), Harbour Antibodies BV (Netherlands), Oncodesign (France), Pharmatest Services (Finland), Ozgene Pty Ltd. (Australia), TransCure services (France), Cyagen Biosciences (US), Aragen Life Sciences Ltd. (India), GemPharmatech (China), and Biocytogen (US). Recent Developments: In January 2022, Taconic Biosciences, Inc. (US) launched the huNOG-EXL EA (early access) humanized immune system (HIS) mouse. In October 2021, The Jackson Laboratory (US) acquired RMS Business of Charles River Laboratories Japan, Inc. (Japan) which is Charles River Laboratories Japan's Research Models & Services (RMS) business as a wholly-owned subsidiary. In September 2021, Biocytogen (US) collaborated with Envigo (US) in order to support the research applications of the triple immunodeficient B-NDG mouse. Envigo is the exclusive provider of B-NDG mice in the US, Europe, and certain APAC regions. In March 2021, Charles River Laboratories International, Inc. (US) acquired Cognate BioServices, Inc. (US) a cell and gene therapy contract development and manufacturing organization (CDMO) offering comprehensive manufacturing solutions for cell therapies. The acquisition expanded Charles River's broad capabilities across the major CDMO platforms for cell and gene therapies. Get 10% Free Customization on this Report: Humanized Mouse and Rat Model Market Advantages: Predictive Validity: Humanized models closely mimic human physiology, genetics, and immune responses, providing a more accurate representation of human disease progression and treatment outcomes. This predictive validity enhances the reliability of preclinical data and improves the likelihood of successful translation to clinical trials. Reduced Ethical Concerns: Using humanized models reduces the need for animal testing on non-human species, addressing ethical concerns and promoting more humane research practices. Personalized Medicine: These models can be customized to replicate specific patient profiles or disease conditions, enabling personalized medicine approaches for tailored treatment strategies. Drug Efficacy and Safety Screening: Humanized models allow for rigorous assessment of drug efficacy and safety before progressing to human clinical trials, reducing the risk of adverse effects and optimizing the drug development process. Understanding Disease Mechanisms: By closely resembling human biology, these models offer valuable insights into disease mechanisms and underlying molecular pathways, advancing our understanding of complex diseases. Rapid and Cost-Effective Research: Humanized models can accelerate research timelines by providing faster results compared to traditional animal models. This efficiency reduces overall research costs and expedites the discovery of novel therapies. Translatability to Humans: The ability of humanized models to recapitulate human responses enhances the likelihood of successful translation of research findings to human patients, fostering more effective treatments. Targeted Therapies: Humanized models facilitate the evaluation of targeted therapies by replicating the specific molecular targets present in human diseases, aiding in the development of precision medicine approaches. Infectious Disease Research: Humanized models are particularly valuable in studying infectious diseases, allowing researchers to study pathogen-host interactions and test potential vaccines and antiviral treatments. Academic and Industry Collaboration: The widespread adoption of humanized models fosters collaboration between academic institutions, pharmaceutical companies, and biotech firms, encouraging a dynamic exchange of knowledge and resources to advance medical research collectively. Overall, the humanized mouse and rat model market represents a pivotal advancement in the biomedical field, enabling researchers to overcome the limitations of traditional models and paving the way for more effective and personalized medical interventions in the future. Related Reports: Mice Model Market - Global Forecasts to 2028 Life Science Instrumentation Market - Global Forecasts to 2028 CRO Services Market - Global Forecasts to 2028 Clinical Trial Supplies Market - Global Forecasts to 2027 Patient Derived Xenograft/PDX Model Market - Global Forecasts to 2026 About MarketsandMarkets™: MarketsandMarkets™ is a blue ocean alternative in growth consulting and program management, leveraging a man-machine offering to drive supernormal growth for progressive organizations in the B2B space. We have the widest lens on emerging technologies, making us proficient in co-creating supernormal growth for clients. The B2B economy is witnessing the emergence of $25 trillion of new revenue streams that are substituting existing revenue streams in this decade alone. 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SAN DIEGO--(BUSINESS WIRE)-- Primmune Therapeutics, a biotech company harnessing the power of the innate immune system to treat solid tumors in the advanced cancer setting and to clear human papillomavirus and related pre-cancerous cervical lesions, today announced that Primmune’s Senior Vice President & Chief Scientific Officer James Appleman, Ph.D., will present at the 4th STING & TLR-Targeting Therapies Summit being held in Boston, Massachusetts from May 9-11, 2023. The oral presentation will cover the recent clinical progress of PRTX007, a systemically active, orally administered prodrug of a novel, small molecule toll-like receptor 7 (TLR7)-specific agonist and will evaluate how the unique pharmacology elicited by PRTX007 distinguishes Primmune’s lead candidate from other TLR7 agonists in human cellular models, in non-human primates, and in the clinical setting. The presentation at the Summit will also review how PRX034, the TLR7 agonist systemically delivered by PRTX007, has been shown to induce engagement of the innate and adaptive immune responses while avoiding systemic inflammation in healthy volunteers, and why PRTX007’s favorable pro expected to correlate with efficacy in cancer therapy. Presentation Details: Title: PRTX007, a Novel Orally Administered TLR7 Agonist Prodrug from Primmune Therapeutics for the Treatment of Cancer Presenter: James Appleman, Ph.D. Date and Time: Wednesday, May 10 at 10 a.m. ET Location: Hilton Boston Back Bay More information on the conference can be found here. About PRTX007 PRTX007, Primmune’s lead clinical development candidate, is designed to provide well-tolerated, controlled, long-term stimulation of the innate immune response while also potentiating long-term effective innate and adaptive immune responses. PRTX007 administration uniquely activates plasmacytoid dendritic cells (pDCs), leading to a systemic immune poly-IFN response without stimulating production of NF-κB-driven proinflammatory factors like IL-6, TNFα or IL-1β. Activated pDCs directly deliver interferons to target cells by paracrine transfer. Conceptually, this is equivalent to administering a therapeutically effective cocktail of all Type I/III IFNs while avoiding the associated side effects and adverse events. Furthermore, PRTX007 administration leads to systemic activation of anti-tumor effector CD8+ T cells and NK cells. PRTX007 is being rapidly advanced towards clinical trials for solid tumors in the advanced cancer setting and for clearing human papillomavirus-transformed pre-cancerous cervical lesions. About Primmune Therapeutics Primmune Therapeutics is a clinical-stage biotech harnessing the power of the innate immune system by developing small molecule, orally administered toll-like receptor 7 (TLR7) agonists for the treatment of solid tumors in the advanced cancer setting and for clearing human papillomavirus-transformed pre-cancerous cervical lesions. For more information, please visit .