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A pos. correlation between massive red meat consumption with colorectal cancer had been reported.Given the complexity of meat components, we focused on investigating the role of Neu5Gc in human healthy.Two groups, either feeding with normal and overdose concentration of Neu5Gc for two weeks, to mimic the normal and overconsumption of red meat conditions in human, resp.The colorectal transcriptomes revealed that Neu5Gc promotes intestinal immune response and identified the hub genes pos. correlated with colorectal cancer such as Tnf, Cd19, Muc13, and Nso2,.The colorectal cancer patients have a 25-30% chance of developing liver metastases, thus we sequenced the liver and revealed the role of Neu5Gc in regulating cell metabolismMoreover, we found that Neu5Gc neg. regulates the expression of Cmah.We conclude that high Neu5Gc intake promotes colorectal inflammatory responses in Apc^Min/+ mice, and suppresses colorectal and hepatic metabolic and digestive processes through Cmah inhibition.

01 Oct 2023·Transplantation

108.3: A transgenic strategy for hEPCR expression in porcine endothelial cells

Author: Pan, Dengke ; Chen, Zhenhui ; Wang, Yong ; Du, jiaxiang

01 Oct 2023·Transplantation

106.5: Comparison of open surgery and ultrasound-guided percutaneous injection on the cytokine response to pig islet xenotransplantation

Author: Liu, Hong ; Deng, Shaoping ; Huai, Guoli ; Zhou, Jia ; Liu, Chunyu ; Tang, Hongmei ; Xie, Yuxuan ; Xing, Xiangyang ; Pan, Dengke ; Qiao, Mu ; Yan, Jie

100 Deals associated with Chengdu Sino-Clone Organ Biotechnology Co., Ltd.

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100 Translational Medicine associated with Chengdu Sino-Clone Organ Biotechnology Co., Ltd.

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