Author: Hidayatullah, Hidayatullah ; Sugihantoro, Hajar ; Taek, Maximus M. ; Maulina, Novia ; Suryadinata, Arief ; Anwar, Mohamad Fajrul ; Ma’arif, Burhan ; Mirza, Denis Mery ; Muslikh, Faisal Akhmal

Neurodegenerative diseases (NDs) are pathological conditions initiated by the loss of neuronal cell structure and the progressive decline in function caused by prolonged neuroinflammation. Postmenopausal women are at a high risk of experiencing NDs due to estrogen deficiency in their bodies, necessitating the administration of phytoestrogens as a replacement for estrogen in the body. One alternative therapy is administering phytoestrogens, estrogen-like substances from plants, which can be obtained from Marsilea crenata C. Presl. leaves. The purpose of this study was to determine whether administration of the n-butanol fraction (BF) and water fraction (WF) of M. crenata leaves could increase locomotor activity in rotenone-induced zebrafish. Treatment was given to each group of zebrafish with BF and WF at doses of 2.5; 5; 10; and 20 ppm to determine the locomotor activity. Then an analysis was carried out by looking at each movement of the zebrafish swimming for 1 min at the time of observation on days 0, 7, 14, 21, and 28. The result showed that BF and WF significantly increased the locomotor activity of zebrafish at the optimum dose of 20 ppm for BF and 5 ppm for WF compared to the negative control. This concludes that the polar fraction of M. crenata leaves is proven to have the potential to prevent ND progressivity.

30 Nov 2023·Research Journal of Pharmacy and Technology

Anti-inflammatory Potency of Pulutan (Urena lobata) Leaf extract and its Fractions by Protein Denaturation Inhibition Assay

Author: Wahyuningsih, Doti ; Purnomo, Yudi ; Tilaqza, Andri

Pulutan (Urena lobata) is a herb which is traditionally used to treat certain diseases and early studies have shown its effectiveness. However, anti-inflammatory activity of herb has not been explored well. The study aim to determine the anti-inflammatory potency of Urena lobata leaf extract and its fraction by the inhibition of protein denaturation. Methanol solvent is used to extract U. lobata leaf by digeration methods therefore concentrated extract was fractionated using n-hexane (Fraction A), ethyl acetate (Fraction B), n-butanol (Fraction C) and aqueous solvent (Fraction D) respectively. The anti-inflammatory potency of medicinal plants was studied by inhibition of protein denaturation and measured using a spectrophotometer at 660 nm wavelength. Half-maximal inhibitory concentrations (IC50) were evaluated for at least five different dose (n = 3) and Ibuprofen as a reference drug. Fraction C is greater to suppress protein denaturation (IC50 = 208,75μg/mL) than fraction A (IC50 = 430,20μg/mL), fraction B (IC50 = 491,69μg/mL) and methanolic extract (IC50 = 338,80μg/mL). However, the inhibitory activity of the fraction and extract on protein denaturation was lower than ibuprofen (IC50 = 79,08 μg/mL). Both of extract and fraction U. lobata leaf have potency to inhibit inflammation but the activity more weak than Ibuprofen as the reference drug.

01 Jan 2023·THE 4TH INTERNATIONAL CONFERENCE ON LIFE SCIENCE AND TECHNOLOGY (ICoLiST)

Modulating effect of soybean (Glycine max) seed and ginger (Zingiber officinale) rhizoma on plasma protein profile of diabetic rat

Author: Wibisono, Nugroho ; Purnomo, Yudi ; Triliana, Rahma

Diabetes mellitus (DM) is associated with protein catabolism due to a decrease in insulin secretion.The profile of plasma protein is a strong predictor of protein metabolism disorder.Glycine max (G. max) and Zingiber officinale (Z. officinalle) are functional food used to cure diseases empirically.However, the potency of herbs to inhibit protein metabolism disorder in DM has not been reported completely.The study aims to examine the effect of G.max and Z. officinale on plasma albumin level, globulin, and total protein of diabetic rats.Diabetic rats (spraque dawley) were induced by High Fructose High Fat Diet (HFHFD) and single-dose streptozotocin 25 mg/kg bw i.p.The 5000 mg/kg bw G.max, 500 mg/kg bw Z. officinale, and its combination was given orally to the rat 4 wk.The level of plasma albumin, globulin, and total plasma protein was measured using a spectrophotometer.The data was analyzed using ANOVA test continued with the LSD test (p<0.05).The oral administration of G.max, Z. officinale, and their combination decreases plasma albumin level, globulin, and total plasma protein compared to the diabetic group (p<0.05).In the diabetic group, plasma albumin level, globulin, and total plasma protein increases compared to the normal group (p<0.05).

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