Magadh University

Asparagus racemosus Willd., a significant medicinal plant in India’s Darjeeling Himalayan region. The current study aims to assess the antidiabetic efficacy of the aerial part of Asparagus racemosus Willd. utilizing a streptozotocin-nicotinamide-induced diabetic rat model. The methanolic extract of plant (ARME) was evaluated for in vitro antidiabetic activity through α-glucosidase and α-amylase enzyme suppression assay and assessed in vivo in a streptozotocin-induced rat model. A 21-day chronic multiple-dose study of ARME was examined. STZ-induced diabetic rats were treated with metformin (70 mg/kg) and ARME at concentrations of 200 and 400 mg/kg. It was discovered that ARME inhibited the activities of α-amylase and α-glucosidase and showed potent therapeutic effects on the rat’s model. ARME helps raise body weight, hemoglobin, and other blood counts and normalizes the serum parameters in the diabetic group. In addition, liver tissues’ abnormal levels of the antioxidant enzymes glutathione and lipid peroxides were returned to those of control animals. HPTLC study revealed the presence of stigmasterol, which showed a strong affinity for the proteins linked to diabetes mellitus through in silico study. As a result of these findings, ARME inhibits the activity of digestive enzymes and has antioxidant and antihyperglycemic effects in STZ-nicotinamide-induced diabetic rats.

This study explores the role of salicylic acid (SA) in reducing oxidative stress in plants by chelating essential metal ions. In vitro experiments examined SA's interaction with metal ions (Mg, Ca, Mn, Fe, Co, Ni, Cu, Zn, Mo), showing that SA and its metal complexes exhibit higher antioxidant activity than ascorbic acid (AA) with radical scavenging activity (RSA) 28.22 % and electrode potential of -0.74 V. Among the complexes, the Mn(II)-SA complex demonstrated the highest antioxidant activity with RSA 64.52 % and electrode potential of -0.9 V. In situ experiments revealed that SA forms complexes more quickly in soil conditions, suggesting effective in-plant chelation. In vivo tests on pesticide-stressed wheat plants showed that the Mn(II)-SA complex enhanced antioxidant enzyme activities (superoxide dismutase (SOD) and peroxidase (POD)). Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) analysis confirmed that SA-treated plants had higher metal content, supporting the idea that SA enhances metal uptake through chelation, thereby mitigating oxidative stress.

Abstract: Eu-doped Calcium Copper Titanate (CCTO) ceramics were synthesized via the solid-state reaction technique and systematically characterized for their structural and dielec. properties.X-ray diffraction (XRD) and Rietveld refinement analyses confirmed that doping of Eu³⁺ ion significantly affects the structure of the Ti-O₆ polyhedra, which in turn influenced their dielec. properties.Impedance spectroscopy revealed that both grain and grain boundary contributions significantly impact the overall conductivity of the Eu-doped CCTO, with the grain boundary resistance dominating at lower temperaturesThe high activation energies associated with grain boundaries suggest the presence of a Schottky barrier potential, which likely contributes to reducing the dielec. loss in the material.Scaling anal. provided insights into the relaxation mechanisms associated with grains and grain boundaries, revealing distinct relaxation zones and highlighting the anisotropic nature of charge distribution at grain boundaries.Overall, the study confirms that Eu doping in CCTO ceramics enhances their dielec. properties by influencing structure of the host matrix as well as grain interior and grain boundary characteristics.These findings offer critical insights into the material′s behavior and present opportunities for optimizing CCTO-based ceramics for advanced high-performance electronic applications.