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Last update 08 May 2025

Scotia Lipidteknik AB

Private Company|Sweden

Last update 08 May 2025

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Translational Medicine

Overview

100 Clinical Results associated with Scotia Lipidteknik AB

0 Patents (Medical) associated with Scotia Lipidteknik AB

Literatures (Medical) associated with Scotia Lipidteknik AB

Multivariate liquid chromatographic optimization strategy in lipid analysis

Author: Kaufmann, P.

The discipline of chemometrics is becoming widely accepted in many fields of chem., chromatog. being an especially prolific area.Statistical exptl. design and response surface modeling minimizes the number of experiments to be performed in the development and optimization process and also provides graphical aids to locate optimal conditions within a given exptl. domain.The practice and science of liquid chromatog. is dynamic and multifaceted, due to the many and diverse types of interactions between the analytes and the stationary and mobile phases that are at play in the separation process.This is even more pronounced for lipid anal. where many classes of lipid mols. are bifunctional by nature, thereby necessitating the use of rational techniques in method development.The authors have developed a pragmatic strategy for chromatog. optimization that allows the analyst to find optimal separation conditions on the basis of literature values or previous scouting runs and the phys. properties of the solvents.The three steps consist of targeting the relevant area in the solvent mixture space, exploring the relevant area and building the prediction model that allows the prediction of optimal conditions.The utility of this strategy will be illustrated in an example of the mol. species anal. of galactolipids.

Progress in Colloid & Polymer Science

Influence of a charged phospholipid on the release pattern of timolol maleate from cubic liquid crystalline phases

Author: S. Engström ; M. Jonströmer ; A. Carlsson ; K. Lindell ; J. Engblom

The release of timolol maleate, a drug for treatment of glaucoma, from cubic liquid crystals consisting of charged and uncharged lipids was investigated in vitro.It was shown that the release of drug was dependent on the ionic strength of the receptor medium and the relative amount of a charged phospholipid in the cubic phase.In the absence of charged lipids, the release of timolol was complete, irresp. of the medium used, i.e. distilled water or saline solutionIn the presence of a neg. charged phospholipid, diacylphosphatidylglycerol, the release of drug from the cubic phase was incomplete when distilled water was the receptor medium.The residual drug was dependent on the amount of charged lipid in the cubic phase.In saline solution, on the other hand, all of the drug was released.The results are interpreted as an effect of electrostatic attraction between the pos. charged drug with the neg. charged bilayer surface, which is screened in the presence of saline.The possible influence of the cubic geometry is discussed as well.This work shows that lipids offer many possibilities in the formulation of sustained drug release systems.

Polar lipids: an industrial view

Author: Herslof, B. G.

A review with no referencesOf all of the natural lipids, oils and fats are used most widely since they are the basis for human nutrition.However, membrane or polar lipids are perhaps the most fascinating in terms of physicochem. properties due to their possibility of interactions with water, making them ubiquitous building blocks and fundamental for life.In fact membrane lipids have been available as industrial materials for a long time in the form of lecithin materials obtained from the processing of fats and oils.At the present time, a number of com. materials exist that are based on or derived from such membrane lipids, mainly phospholipids.The demand for and interest in various types of lipids having industrial functions is increasing, because the number of applications for human use is increasing.Beside the interest in utilizing the functional properties of polar lipids in various formulations, their importance as carrier for specific acyl groups has also become important.The need for tailor-made formulations for food and nutrition, for cosmetic, and pharmaceutical applications has put more demand on the composition of industrial polar lipids.Therefore there is a tendency to look for new materials derived from existing sources or that result from sources not previously utilized for lipids.Glycolipids constitute one family of lipids, previously not utilized on a large scale and that will become increasingly important as industrial polar lipid materials.

100 Deals associated with Scotia Lipidteknik AB

100 Translational Medicine associated with Scotia Lipidteknik AB

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Scotia Lipidteknik AB

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