A review.The purpose of this chapter is to discuss equipment for preparative chromatog. in general, with special emphasis for enantioseparationsA first part of the chapter will address the column itself (bed formation, technologies available, column design, etc.), whether it is used in a batch or a continuous process.In a second part of the chapter, specific items related to equipment for preparative batch chromatog. are discussed.The third section addresses preparative chromatog. with supercritical eluents, and finally the last section is devoted to continuous chromatog. (simulated moving bed and VARICOL).

Journal of Liquid Chromatography & Related Technologies

Principle and applications of supercritical fluid chromatography

Author: Majewski, Wieslaw ; Ludemann-Hombourger, Olivier ; Valery, Eric

A review.One of the most challenging problems encountered during the development of a new pharmaceutical compound is linked to purificationThe synthesis schemes are more and more complex and the request for rapid and efficient methods to isolate the target mol. from mixtures is crucial to ensure the success of the future drug.Preparative chromatog. is widely used at the developmental stages.The technol. offers a perfect answer to the main challenge of the developers: "go fast and be efficient.".The development of a chromatog. separation is easy at this stage; it is often possible to modify an anal. HPLC method to quickly isolate the purified product on a larger column.At the production scale, preparative chromatog. can also be applied.An optimization of the chromatog. conditions at an anal. scale (selection of stationary phase and solvent), together with the selection of the appropriate chromatog. process (discontinuous or continuous), lead to a cost effective, efficient, and robust industrial process.Preparative chromatog. is applied at a very large scale for the purification of small organic mols., peptides and proteins, carbohydrates, and chiral mols. under conditions required for pharmaceutical applications.Even though preparative gas chromatog. is successfully implemented for some applications at the industrial scale concerning low mol. weight and/or very volatile compounds, liquid eluents are by far the most common and competitive choice for the preparative chromatog. process.

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