Antitumor imidazo[5,1-d]-1,2,3,5-tetrazines: compounds modified at the 3-position overcome resistance in human glioblastoma cell lines
Author: Bradshaw, Tracey D. ; Frigerio, Mark ; Cousin, David ; Matthews, Charles S. ; Stevens, Malcolm F. G. ; Hummersone, Marc G. ; Zhang, Jihong
Imidazotetrazines substituted at the N-3 position overcome resistance or tolerance to temozolomide conferred, respectively, by MGMT or DNA MMR defects.
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