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Last update 08 May 2025

Eastman Dental Center

Education|New York, United States

Last update 08 May 2025

Overview

Pipeline

Deal

Translational Medicine

Overview

Clinical Trials associated with Eastman Dental Center

NCT06866327

/ RecruitingNot ApplicableIIT

Feasibility and Acceptability of Music Training Programs Among Older Adults Living with Mild Cognitive Impairment: a Pilot Randomized Controlled Trial

The goal of this pilot clinical trial is to learn if older adults with mild cognitive impairment (MCI) find two music programs equally acceptable. This pilot study will help researchers prepare for a future, large-scale clinical trial to learn if music training can slow cognitive decline and promote emotional well-being in those at risk for Alzheimer's disease and related dementias. The main questions this pilot study aims to answer are:
* Do participants like the music programs?
* Do participants stay enrolled in the study?
* Do participants report perceived benefits of the programs for their emotional well-being or everyday memory?
Participants will:
* Participate in 12-weekly sessions of piano lessons or music lessons, with group and individual lessons alternating each week.
* Have home practice in between lessons, with a keyboard or other instruments provided.
* Keep a diary of their home practice and their mood before and after practice.
* Participate in interviews before and after the 12-week programs.

Start Date24 Feb 2025

Sponsor / Collaborator

University of Rochester

[+1]

100 Clinical Results associated with Eastman Dental Center

0 Patents (Medical) associated with Eastman Dental Center

215

Literatures (Medical) associated with Eastman Dental Center

01 Aug 2009·Implant DentistryQ4 · MEDICINE

Platelet-Rich Plasma: A Literature Review

Q4 · MEDICINE

Review

Author: Ren, Yan-Fang ; Romanos, Georgios E ; Ramanayake, Thaminda ; Arora, Navneet S

Platelet-rich plasma (PRP) is an autologous concentration of platelets in concentrated plasma, which is extensively used to promote soft and hard tissue healing. The significance behind its use refers to the abundance of growth factors present in a well-prepared PRP concentrate. These growth factors enhance the rate and quality of wound healing by different mechanisms. The objective of this review article is to explain the biological aspect of hard and soft tissue healing by application of PRP in conjunctions with its molecular basis.

15 Aug 2007·Cancer ResearchQ1 · MEDICINE

Sequential Down-regulation of E-Cadherin with Squamous Cell Carcinoma Progression: Loss of E-Cadherin via a Prostaglandin E2-EP2–Dependent Posttranslational Mechanism

Q1 · MEDICINE

Article

Author: Kyrkanides, Stephanos ; McGrath, Kieran H. ; Brouxhon, Sabine ; Scott, Glynis ; Miller, Jen-nie H. ; Erdle, Brandon ; Pentland, Alice P. ; Schneider, Sandra ; O'Banion, M. Kerry ; Johnson, Renee ; Pearce, David A. ; VanBuskirk, JoAnne ; Centola, Gina M.

AbstractThe incidence of skin cancer is on the rise, with over 1 million new cases yearly. Although it is known that squamous cell cancers (SCC) are caused by UV light, the mechanism(s) involved remains poorly understood. In vitro studies with epithelial cells or reports examining malignant skin lesions suggest that loss of E-cadherin–mediated cell-cell contacts may contribute to SCCs. Other studies show a pivotal role for cyclooxygenase-dependent prostaglandin E2 (PGE2) synthesis in this process. Using chronically UV-irradiated SKH-1 mice, we show a sequential loss of E-cadherin–mediated cell-cell contacts as lesions progress from dysplasia to SCCs. This E-cadherin down-regulation was also evident after acute UV exposure in vivo. In both chronic and acute UV injury, E-cadherin levels declined at a time when epidermal PGE2 synthesis was enhanced. Inhibition of PGE2 synthesis by indomethacin in vitro, targeted deletion of EP2 in primary mouse keratinocyte (PMK) cultures or deletion of the EP2 receptor in vivo abrogated this UV-induced E-cadherin down-regulation. In contrast, addition of PGE2 or the EP2 receptor agonist butaprost to PMK produced a dose- and time-dependent decrease in E-cadherin. We also show that UV irradiation, via the PGE2-EP2 signaling pathway, may initiate tumorigenesis in keratinocytes by down-regulating E-cadherin–mediated cell-cell contacts through its mobilization away from the cell membrane, internalization into the cytoplasm, and shuttling through the lysosome and proteasome degradation pathways. Further understanding of how UV-PGE2-EP2 down-regulates E-cadherin may lead to novel chemopreventative strategies for the treatment of skin and other epithelial cancers. [Cancer Res 2007;67(16):7654–64]

01 Jan 2003·The LancetQ1 · MEDICINE

Conjugal Parkinson's disease

Q1 · MEDICINE

Article

Author: Counihan, Timothy J

252 THE LANCET • Vol 361 • January 18, 2003 • www.thelancet.com 7 Burgio GR, Locatelli F. Transplant of bone marrow and cord blood hematopoietic stem cells in pediatric practice, revisited according to the fundamental principles of bioethics. Bone Marrow Transplant 1997; 19: 1163–68. 8 Annas GJ. Waste and longing: the legal status of placental-blood banking. N Engl J Med 1999; 340: 1521–24. 9 Sugarman J, Kaalund V, Kodish E, et al. Ethical issues in umbilical cord blood banking. JAMA 1997; 278: 938–43. 10 Marshal E. Clinical promise, ethical quandary. Science 1996; 271: 586–88. 11 Alby N. Le cancer, sens et non sens. Rev Med Psychosomat 1987; 9: 15–36. 12 Horowitz MM, Gale RP, Sondel PM, et al. Graft-versus-leukemia reactions after bone marrow transplantation. Blood 1990; 75: 555–62. 13 Ford AM, Bennett CA, Price CM, Bruin MC, Van Wering ER, Greaves M. Fetal origins of the TEL-AML1 fusion gene in identical twins with leukaemia. Proc Natl Acad Sci USA 1998; 95: 4584–88. 14 Beauchamp TL, Childress JF. Principles of biomedical ethics. Oxford University Press: New York, 1994. 15 Burgio GR, Nespoli L, Porta F. Programming of bone marrow donor for a leukaemic sibling. Lancet 1987; 1: 1484–85. 16 International Working Group on preimplantation genetics. Preimplantation genetic diagnosis—an integral part of assisted reproduction: report of the 9th annual meeting of the International Working Group on preimplantation genetics, in association with the 11th IVF Congress, Sydney, Australia; May 10, 1999. J Ass Reprod Gen 2000; 17: 75–79. 17 Handsyde AH, Kontogianni EH, Hardy K, Winston RM. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature 1990; 334: 768–70. 18 Jones HW Jr. New reproductive tecnologies. Baillieres Best Prac Res Clin Obstet Gynaecol 1999; 13: 473–90. 19 Damewood MD. Ethical implications of a new application of preimplantation diagnosis. JAMA 2001; 285: 3143–44. 20 Verlinsky Y, Rechitsky S, Schoolcraft W, Strom C, Kuliev A. Preimplantation diagnosis for Fanconi anaemia combined with HLA matching. JAMA 2001; 285: 3130–33. 21 Burgio GR, Locatelli F. Ethics of creating programmed stem-cell donors. Lancet 2000; 356: 1868–69. 22 Dufour C, Rondelli R, Locatelli F, et al. Stem cell transplantation from HLA-matched related donor for Fanconi’s anaemia: a retrospective review of the multicentric Italian experience on behalf of Associazione Italiana di Ematologia ed Oncologia Pediatrica (AIEOP)—Gruppo Italiano Trapianto di Midollo Osseo (GITMO). Br J Haematol 2001; 112: 796–806.

100 Deals associated with Eastman Dental Center

100 Translational Medicine associated with Eastman Dental Center

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Eastman Dental Center

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