December 10, 2015
By
Alex Keown
, BioSpace.com Breaking News Staff
NEW YORK --
Kallyope Inc.
, a new biotech company focused on harnessing the potential of the gut-brain axis,
launched
this morning backed by $44 million in Series A funding and is being helmed by
Nancy Thornberry
, a
Merck & Co.
vet with a specialty in diabetes and endocrinology.
New York-based
Kallyope
was founded with an idea of harnessing the communicative pathways between the digestive tract and the brain to develop therapies to treat various illnesses. Thornberry said the company’s approach would not have been possible a few years ago, but since the discovery of the “gut-brain circuits” the company can develop a range of therapeutic approaches.
In an
interview
with Forbes, Thornberry said the company’s technology will look at ways in which cells in the intestines actually affect the brain, signaling such things as whether or not the body is still hungry, or if there is some sort of discomfort. She said the technology can help the company focus on several disease areas, as well as a possibility of developing consumer products. However, what those areas are, the company has not yet disclosed. The company said it will leverage cutting-edge technologies including sequencing, genetics, circuit mapping, neural imaging and bioinformatics.
“The gut-brain axis functions as a two-way information highway between the gut and the brain, providing an unprecedented opportunity to access and influence brain centers involved in a variety of fundamental human processes.
Kallyope
has put together an exciting, state-of-the-art program to understand how the gut communicates with other organs and our brains about our physiological, metabolic and internal state,”
Tom Maniatis
, a co-founder of
Kallyope
and a professor in the Department of Biochemistry and Molecular Biophysics at
Columbia University College of Physicians and Surgeons
, said in a statement.
Thornberry told Forbes the company’s technology would have likely been able to discover the GLP-1 (glucagon like peptide-1) which can be used to treat diabetes. GLP-1-based drugs are manufactured by a number of companies, including Danish-based
Novo Nordisk
.
Novo Nordisk
manufactures
several GLP-1 diabetes treatments, including Victoza, which is marketed under the brand name Saxend in the United States. In April,
Novo Nordisk
announced its
Saxend
, a once-daily glucagon-like peptide-1 (GLP-1) receptor agonist for chronic weight management in adults, was available for sale in the United States. Obese individuals often develop type 2 diabetes.
The company is backed by investments from
Lux Capital
,
Polaris Partners
and
The Column Group
. Other notable investors include
Illumina Inc.
,
Tony Evnin
, and
Alexandria Venture Investments
,
Kallyope
said in a statement.
“What
Kallyope
is doing represents a hugely exciting venture into the untapped therapeutic and nutritional potential of the gut-brain axis, which no other biotech has unlocked and translated. We believe that
Kallyope
is pioneering an area of science that will fundamentally change how drugs and nutritional products are made, targeted, and administered,”
Josh Wolfe
,
Kallyope
board member and managing partner of
Lux Capital
, said in a statement.
Kallyope
has taken over laboratory space at the
Alexandria Center for Life Science
, a state-of-the-art, collaborative life science campus in Manhattan.
Kallyope
said the location will allow it to “draw upon the city’s deep talent pool and diverse resources.”