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Last update 08 May 2025

University of Science and Technology of Hanoi

Dissolved

| Education|

www.usth.edu.vn

Dissolved

| Education|

www.usth.edu.vn

Last update 08 May 2025

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Translational Medicine

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100 Clinical Results associated with University of Science and Technology of Hanoi

0 Patents (Medical) associated with University of Science and Technology of Hanoi

680

Literatures (Medical) associated with University of Science and Technology of Hanoi

03 Jun 2025·Chemical Engineering Communications

Effective adsorbents developed from magnetic iron oxides and thiamin for the removal of hazardous organic contaminants

Author: Tran, Thi Thanh Khuong ; Angkawijaya, Artik Elisa ; Ly, Kim-Phung ; Nguyen, Minh-Nhut ; Tran, Nguyen-Phuong-Dung ; Nguyen, Hong-Nam ; Huynh, Quoc-Khanh ; Santoso, Shella Permatasari ; Tran-Nguyen, Phuong Lan ; Yuliana, Maria

Among the removal techniques for organic contaminants in water, adsorption is a highly selected method due to many advantages in cost, simple process, and good efficiency.A green and straightforward synthesis for generating an iron oxide-grafted thiamin based adsorbents is developed.Their physicochem. and adsorption properties varied depending on the mixing ratio of ferrous chloride salt and thiamin.Adsorbents exhibited different magnetic properties owing to the presence of Fe₃O₄, α-Fe₂O₃, and γ-Fe₂O₃ crystalline phases.Their surface charges of iron oxide and functionalized thiamin-adsorbents were 25 mV and 30-52.3 mV, resp. while the C and N contents of thiamin ranged from 3.87-14.5% and 3.95-8.15% at different mixing ratios.Besides, scanning electron microscope (SEM) and thermogravimetric anal. (TGA) were used to analyze the morphol. and thermal stability of adsorbents, resp.This work investigated the effect of thiamin content in the material composition-based iron oxide on the adsorption capacity of anionic dyes.At the optimal condition (pH 5, an adsorbent dosage of 2 g/L, and a 30 mg/L concentration), the MO adsorption efficiency reached 77.56% in 30 min.Meanwhile, a 93.83% EBT was removed at pH 7, an adsorbent dosage of 2 g/L, and a 90 mg/L concentration at the same time.The adsorption mechanism follows the Langmuir isotherm model and the pseudo second-order (PSO) kinetic model.The adsorption processes are spontaneous and exothermic.The characteristic vibrations of functional groups of adsorbents were identified via Fourier transform IR spectroscopy (FTIR).After four cycles, adsorbents could be employed albeit with a lower efficiency.

03 May 2025·International Journal of Environmental Analytical Chemistry

Analysis of perfluoroalkyl compounds in marine fish muscle samples by liquid chromatography tandem mass spectrometry

Author: Duong-Thi, Quynh-Mai ; Le, Minh-Thuy ; Vu-Cam, Tu ; Nguyen, Thao Thi ; Chu, Dinh Binh ; Nguyen, Huong Thi ; Vu-Duc, Nam ; Bui, Van-Hoi ; Nguyen, Hoang-Anh ; Nguyen, Thu Thi

In this work, a reversed phase chromatog. tandem mass spectrometry has been used for anal. of 23 perfluoroalkyl substances in marine fish muscle samples.Fish samples was collected, codded and dried via freeze-dried and homogenised, and poly/perfluoroalkyl substances (PFASs) were extracted by ultrasonic assisted ion pair liquid-liquid extractionThe extractant was then cleaned up with solid phase extraction with different absorbents.To avoid carry-over, contamination/losing target analytes during SPE step, a simple one-step centrifugal SPE was used.All parameters of the anal. method such as linearity range, stability of anal. signal, LOD, and LOQ of the anal. method have been investigated and presented.Limit of quantification of the method was from 0.04μg kg-1 to 0.45μg kg-1 for the wet weight sample.Matrix effect was investigated and eliminated by solid phase extractionOverall recovery of the PFASs in range of 44%-132% was achieved.Excellent repeatability of anal. signal in both short-term and long-term were below 9.0% and 16%, resp.The anal. method has been validated by using certified reference material, NIST 1947.The validated anal. method was then used for anal. of PFASs in edible fish samples that collected in several coastal sites in Vietnam.The results showed that the main compounds in marine fish samples were perfluorooctanesulfonate (PFOS) and 2:6-FT.However, concentration of PFOS and its derivatives in all analyzed marine fish samples was below European Union maximum allowable concentration

01 Apr 2025·International Journal of Pharmaceutics

Comparative stabilization mechanism of self-assembling fattigated gelatin, micellar polyethylene glycol hexadecyl ether, and electrostatic interactive xanthan gum for aqueous labile decitabine

Article

Author: Ngo, Hai Van ; Gil, Myung-Chul ; Park, Chulhun ; Jin, Gang ; Park, Jun-Bom ; Lee, Beom-Jin ; Nguyen, Hy Dinh ; Lee, Sang Min ; Nguyen, Van Hong

Decitabine (DCB) is very unstable in aqueous solutions because of the opening of the N-5 and C-6 aza-ring. The objective of this study was to investigate a stabilization mechanism of aqueous-labile decitabine (DCB) with three different materials by preparing binary spray dried powders (SDs): self-assembling fattigated gelatin-oleic acid conjugate (GOC), micellar polyethylene glycol hexadecyl ether (Brij® 58), nonionic surfactant and electrostatically interactive xanthan gum (XA), an anionic polysaccharide. GOC was synthesized by covalently conjugating oleic acid with gelatin. The degradation rate of intact DCB was highly dependent on the solution conditions, showing stability in the following decreasing order: pH 1.2 < pH 4.5 < pH 6.8 < pH 7.4 < deionized water (DW) < 50 % ethanol. DCB was the most unstable in the low pH 1.2 solution, with only 25.1 % remaining after 2 h. As the GOC content (DCB: GOC = 1:5, 1:10, 1:50) increased in the GOC SDs, the degradation rate of DCB decreased proportionally because GOC readily formed nanoparticles (NPs) with a critical micelle concentration (CMC) of 0.0416 mg/mL to protect DCB against degradation. This nano-forming behaviors of GOC was also visualized using field emission transmission electron microscope (FE-TEM) and field emission scanning electron microscope (FE-SEM). Brij® 58 SD (DCB: Brij® 58 = 1:10) slightly increased the DCB stability via micellization above CMC for a short period of time as compared to the DCB control. In contrast, XA had more favorable stabilizing effect at a low pH 4.5 solution via polyelectrolyte complex formation of positively charged DCB and negatively charged XA compared with other XA SD prepared in DW or pH 6.8 solution. Among the three stabilizing materials, GOC provided the highest stabilization capacity via the nanonization process compared with micellar Brij® 58 and electrostatically interactive XA. Furthermore, the molecular hydrogen bonding interactions and amorphousness of DCB with GOC, Brij® 58, and XA contributed to the stabilization of DCB according to instrumental analyses such as Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). The in vitro release of GOC SDs was maintained at pH 1.2 and pH 6.8, while DCB alone was rapidly released and then degraded. The more GOC used, the more DCB release delayed. The release rate of Brij® 58 SD was released immediately but gradually decreased. However, XA SD also rapidly released DCB, which then degraded in a steeper manner. The release profiles of DCB were governed by the balanced effect of the stabilization capacity in the solution and loading contents of three stabilizing materials in SDs formulations.

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100 Translational Medicine associated with University of Science and Technology of Hanoi

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