Author: Baskar, Gomathy ; Balaramnavar, Vishal M ; Rab, Safia Obaidur ; Kaliamoorthy, Senthilkumar ; Kaliaperumal, Kumaravel ; Kumarasamy, Saravanan ; Palaniyandi, Thirunavukkarasu ; Nagarajan, Akshaya ; Manikandan, Monica Shri ; Varadhan, Varsha

Cancers are a class of disorders that entail uncontrollably unwanted cell development with dissemination. One in six fatalities globally is attributed to cancer, a global health issue. The analysis of the entire DNA sequence and how it expresses itself in tumor cells is known as cancer genomics. The development of novel cancer treatments has been facilitated because of the genomics method. COL10A1 gene, a short chain collagen, and an interstitial matrix component, acts as a predictive biomarker for cancer prognosis. Recognizing the fundamental consequences of mutations in the COL10A1 gene and its expression in cancer is crucial. Analyzing the COL10A1 gene expression with a data set and gene expression patterns shows the level of display of the tumor. Examining the therapeutic techniques of COL10A1 gene expression leads to early detection, screening, radiation therapy, and advanced developments. This review highlights the value of the COL10A1 gene in breast, gastric, pancreatic, lung, and colorectal cancers, emphasizing its role in gene expression patterns and therapeutic techniques.

31 Dec 2024·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Experimental study on diesel engine working characteristics using yellow oleander biodiesel with the effect of different injection timings

Author: Senthil Kumar, Krishnan Ramachandran ; Rajan, Kuppusamy

This research work investigates the influence of different injection timing (IT) on working characteristics of an engine with 20% Yellow Oleander biodiesel (YOBD20) blend.Exptl. tests have been conducted with a YOBD20 blend at different ITs such as 23°BTDC, 25°BTDC, and 21°BTDC were original, advanced, and retarded ITs.From the exptl. results, BTE of YOBD20 with advanced IT of 25°bTDC increased by about1.24% higher than YOBD20 at original IT, while the BSFC was diminished by 9% and the NOx emission were increased by 14.2%, while CO, HC, and smoke emissions were decreased by 26.2%, 22%, and 28%, resp., when contrast with diesel at original IT of 23°BTDC.Further, the NOx emission was diminished by 32% for YOBD20 with retarded IT of 21°BTDC with the penalty of BTE by 0.896% and the other emissions were increased as compared to diesel at original IT.The cylinder pressure, heat release rate (HRR) and rate of pressure rise (ROPR) were increased at advanced IT and for the retarded IT, the performance was slightly inferior due to slow combustion.Further, the NO emission would be reduced with the help of adopting with exhaust gas recirculation (EGR) along with retarding the injection timing.

31 Dec 2024·Fizjoterapia Polska

Evaluation of stretch shortening cycle and conventional exercise for lateral epicondylitis: A pilot study

Author: Mary, S.M. Divya ; Hema, V. H. ; Senthil, P. ; Pau, Jibi

Introduction. Lateral epicondylitis, or tennis elbow, is a common musculoskeletal condition caused by repetitive strain on the elbow joint, often affecting individuals engaged in repetitive wrist and forearm motions. It leads to inflammation and microtears in the extensor tendons, resulting in pain, impaired grip strength, and difficulties in daily activities. Management typically involves conservative treatments, with therapeutic exercises playing a crucial role. Recent methods, such as stretch shortening cycle (SSC) exercises, utilize elastic energy to enhance rehabilitation outcomes. Aim. This study compares the effectiveness of SSC exercises and traditional exercise protocols in improving grip strength and functional outcomes in patients with unilateral lateral epicondylitis. It also assesses the interventions’ impact on activities of daily living using the Patient-Rated Tennis Elbow Evaluation (PRTEE) and a patient-specific functional scale. Methods. Conducted at the ACS Medical College and Hospital, the study involved 24 participants aged 45–65 years with unilateral lateral epicondylitis. Participants were randomly assigned to Group A (SSC exercises) or Group B (traditional exercises). Group A performed SSC exercises combining eccentric and immediate concentric phases, while Group B engaged in conventional strengthening and stretching exercises. Both groups completed a 12-week program. Assessments included grip strength (dynamometer), PRTEE scores, and a functional scale. Statistical analysis compared pre- and post-intervention results. Results. Both groups showed significant improvements in grip strength and functional outcomes, with SSC exercises yielding superior results. PRTEE scores revealed reduced pain and improved functionality, with statistically significant differences favoring SSC exercises (p < 0.05). The effect size for grip strength was small (Cohen’s d = 0.062), and the number needed to treat (NNT) was 17, suggesting modest clinical benefits. Conclusion. SSC exercises are more effective than traditional protocols in improving grip strength and functional performance in lateral epicondylitis, supporting their use in rehabilitation strategies.

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