In a continuous production system of pharmaceutical tablets, the mixing accuracy of the continuous mixing process before the molding process is important.It is known that the supply accuracy of the quant. feeder used in the weighing process plays an extremely important role in ensuring the mixing accuracy.Therefore, author have developed a new loss-in-weight quant. feeder and controller with new functions.In the development, author also considered establishing a control method that enables stable supply even during the addnl. input of powder.In this paper, author reported the results of performance evaluation of the newly developed quant. feeder.

10 May 2020·Journal of the Society of Powder Technology, Japan

Development of Direct Compression Continuous Manufacturing System for Low-Dose Drug Products

Author: Watano, Satoru ; Takusagawa, Shota ; Horibe, Masashi ; Fushimi, Shinsuke ; Sonoda, Ryoichi

A continuous direct compression process for a low-dose drug product was proposed.Acetaminophen was used for the model drug, and the mixing and tableting experiments with the low content were conducted using direct compression continuous manufacturing system.A low-dose continuous mixing was conducted in two steps.It was found that it is important to select the similar particle size for both drug and excipient in the first step mixing, and the result of the tableting experiment, the tablet contained 1% API indicated the good content uniformity.The exptl. result of the second step, it was difficult to obtain the tablet contained 0.01% API with the good content uniformity.It was suggested that it is important to use jet-milled drug instead of using non-pulverized drug in the second step.

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