Delving into the Latest Updates on Shanghai Pudong New District Zhoupu Hospital with Synapse

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Immune System Diseases

Endocrinology and Metabolic Disease

Infectious Diseases

Small molecule drug

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Disease Domain	Count

Immune System Diseases	1
Endocrinology and Metabolic Disease	1
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

NOS2(Nitric oxide synthase, inducible)	1

AbstractIntroduction:Cardiovascular disease (CVD) is the top global killer, with work stress as a risk factor. The choice of assessment tools for work stress significantly affects our understanding of its role in CVD outcomes. This systematic review and meta-analysis focused on comparing the efficacy of different work stress assessment tools in predicting cardiovascular events.Methods:We searched PubMed, Web of Science, Scopus, Cochrane, and Embase databases through December 2023 for cohort studies quantifying the association between work stress and cardiovascular events. Using predefined criteria, we extracted data and conducted random- or fixed-effects meta-analyses to calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Sensitivity analyses were conducted using the literature-by-exclusion method and the fill-and-trim method.Results:Eighteen articles involving 257,101 subjects were included. Work stress increased the risk of cardiovascular events by 26% (HR = 1.26; 95%CI: 1.19–1.34; P < 0.001). The job content questionnaire showed a significant association (HR = 1.25; 95% CI: 1.17–1.34; P < 0.001; I2 = 11.4%) The effort–reward imbalance scale also indicated significance but with heterogeneity (HR = 1.30; 95%CI: 1.15–1.47; P = 0.084; I2 = 54.9%). When categorized by event type, increased work stress is linked to an elevated risk of cardiovascular events, particularly coronary heart disease and myocardial infarction, though not with stroke.Conclusion:The JCQ is recommended for studying work stress and cardiovascular health. While publication bias is possible, our findings are robust. However, limitations due to heterogeneity and studies’ number highlight the need for further research.

01 Aug 2024·IEEE Transactions on Biomedical Circuits and Systems

An Energy-Efficient FD-fNIRS Readout Circuit Employing a Mixer-First Analog Frontend and a $\Sigma$-$\Delta$ Phase-to-Digital Converter

Article

Author: Qi, Liang ; Sawan, Mohamad ; Zhao, Jian ; Chen, Cheng ; Wang, Guoxing ; Lin, Yuxiang ; Li, Yongfu ; Ma, Zhouchen ; Bi, Xia

This paper presents a low-power frequency-domain functional near-infrared spectroscopy (FD-fNIRS) readout circuit for the absolute value measurement of tissue optical characteristics. The paper proposes a mixer-first analog front-end (AFE) structure and a 1-bit Σ-Δ phase-to-digital converter (PDC) to reduce the required circuit bandwidth and the laser modulation frequency, thereby saving power while maintaining high resolution. The proposed chip achieves sub-0.01° phase resolution and consumes 6.8 mW of power. Nine optical solid phantoms are produced to evaluate the chip. Compared to a self-built high-precision measurement platform that combines a network analyzer with an avalanche photodiode (APD) module, the maximum measuring errors of the absorption coefficient and reduced scattering coefficient are 10.6% and 12.3%, respectively.

01 Aug 2024·Diagnostic Microbiology and Infectious Disease

Lemierre's syndrome complicating multiple organ failure caused by Fusobacterium necrophorum subsp. funduliforme F1260: Case report and review

Review

Author: Li, Xiaoyan ; Wang, Ruixue ; Han, Xiaonan ; Zhang, Lizhong

We described a case of a 24-year-old man with multiple organ failure caused by Fusobacterium necrophorum subsp. funduliforme F1260. This is the first described case of Lemierre's syndrome with multiple organ failure due to F. necrophorum subsp. funduliforme F1260 in an adult in China. Our study highlights that there may be a risk of misdiagnosis based solely on typical manifestations of internal jugular vein thrombophlebitis, metastatic lesions, and F. necrophorum isolated from blood cultures or normally sterile sites. Clinicians should be cognizant of the potential utility of metagenomic next-generation sequencing in facilitating early pathogen detection in severe infections, thus enabling timely and appropriate administration of antibiotics to reduce mortality rates and improve prognosis.

100 Deals associated with Shanghai Pudong New District Zhoupu Hospital

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100 Translational Medicine associated with Shanghai Pudong New District Zhoupu Hospital

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Pipeline

Pipeline Snapshot as of 08 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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