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Content determination of main component in sunitinib malate capsules by HPLC
Author: Feng, Ya-ning ; Zhou, Hui-qin
The aim is to establish a method for the content determination of main component in sunitinib malate capsules.HPLC method was adopted.Shimadzu C18 column was used with mobile phase of ammonium acetate buffer(pH 6.8)-acetonitrile(55:45) at the flow rate of 1.0 mL·min-1.The detection mavelength was set at 430 nm and column temperature was 35°C.The linear range of sunitinib malate was 5∼25μg·mL-1(r=0.9997) with an average recovery of 99.65%(RSD=0.66%, n=9).The method is simple, accurate and precise, and it is applicable for the determination of sunitinib malate capsules.
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