Compliance by clients with prescribed health care regimens has become an area of intense interest for health care providers. With statistics pointing to the fact that patient compliance can range anywhere from 10% to 94%, there is a definite need for strategies that are available to health care providers, in particular nurses, to assist clients in adhering to their health care regimens. Although much research has been done to measure compliance and identify determinants, little has been done in the area of developing specific strategies and interventions to assist clients with their lifestyle changes. Nurses, using empirically validated nursing interventions to treat identified problems or nursing diagnoses, are in the unique position of being able to impact and enhance the clients' ability to adhere to their prescribed regimens. In this study a total of 225 nursing activities were identified to operationalize the five selected nursing interventions and were rated by 32 master's-prepared nurses certified in the area of diabetes education and psychiatric/mental health. Four activities received weighted ratios of less than 0.50 and were thus discarded. One hundred nine (48%) received ratios of less than 0.80 and are considered minor supporting activities, and 112 (50%) were weighted as greater than or equal to 0.80 and are thus considered major supporting activities. The ICV scores for the five nursing interventions ranged from 0.76 to 0.81.