Anurans from the Early–Middle Miocene Santa Cruz Formation at Río Chalía (Patagonia, Argentina), and a revision of the fossil Calyptocephalellidae (Anura: Australobatrachia)

Author: Bargo, M. Susana ; Muzzopappa, Paula ; Vizcaíno, Sergio F.

01 May 2025·Molecular and Cellular Endocrinology

Maternal dopamine agonist treatment before pregnancy reverses infertility and hyperprolactinemia in hCG-overexpressing mice through lactation: Evidence of generational effects

Article

Author: Ratner, Laura D ; Huhtaniemi, Ilpo ; Marcial Lopez, Agustina ; Poutanen, Matti ; Rulli, Susana B ; Di Giorgio, Noelia P

Dopamine agonists, such as cabergoline (Cab), have demonstrated efficacy in restoring reproductive function in cases of hyperprolactinemia and hormonal dysregulation. This study investigates the long-term consequences of maternal Cab treatment on the reproductive phenotype of the progeny in a female transgenic (TG) mouse model with hyperprolactinemia and infertility due to human chorionic gonadotropin (hCG) β-subunit overexpression. The TG females that received Cab between weeks 3-4 of life exhibited a reversion of hyperprolactinemia and infertility, whereas WT females retained their fertility. When TG-cab- or WT-Cab-treated females were crossed with WT or TG males, respectively, their female TG offspring showed a reversal of precocious puberty, regularization of estrous cycles, fertility, and prevention of hyperprolactinemia and prolactinomas. Despite the persistent high LH/hCG bioactivity, the normalization of prolactin levels led to a reduction in ovarian luteinization markers and progesterone levels. The TG female pups born to either WT-cab- or TG-cab-treated females exhibited a normalized phenotype, thus suggesting that the effects were indeed due to maternal Cab administration, and not to the transgene. Cross-fostering experiments showed that the long-lasting programming effect of maternal Cab on offspring occurred during lactation because the TG female pups from non-treated WT female/TG male pregnancies, but nursed by Cab-treated females, were free from the altered TG phenotype. These results suggest that Cab treatment before pregnancy may have a multigenerational effect on the hypothalamic-pituitary-gonadal axis of the offspring, mediated during lactation. This highlights potential implications for generational health and clinical practices regarding the use of dopamine agonists during lactation.

03 Apr 2025·Historical Biology

A Late Cretaceous lizard assemblage from the Allen Formation, northern Patagonia, Argentina

Author: Gómez, Raúl O. ; Garberoglio, Fernando F. ; Rougier, Guillermo W. ; Apesteguía, Sebastián

100 Deals associated with Universidad Maimónides

100 Translational Medicine associated with Universidad Maimónides

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