Delving into the Latest Updates on Shanghai Zannan Technology Co., Ltd. with Synapse

Overview

Basic Info

Introduction

Zannan SciTech Co., Ltd. was founded by Zhan James Zheng-Yun in 2003 and is headquartered in Shanghai, China. It operates as a pharmaceutical contract research organization and polymer development company. It offers products and technology services, and it also provides hydrogenated nitrile butadiene rubber; HCV inhibitors; and polydicyclopentadiene, a polymer that is used as a plastic material in car, pipe, and building materials.

HNBR is a kind of high performance hydrogenated nitrile specialty rubber, which was broadly used in the car and oil industries.HNBR was traditionally prepared by hydrogenation with either Pd or Rh catalysts.This presentation discloses a unique manufacturing technol. and uses developed with Zhan Catalysts by Zannan SciTech Company in China.So far, different grades of HNBR products (Zhanber) have been prepared with broad range of phys. properties and uses, such as 20-50% acrylonitrile content, 90-99% hydrogenated saturation and 20-130 Mooney viscosity grades.Moreover, it is noteworthy that Zhanber HNBR with low Mooney viscosity grades such as ZN35153 (36±1.5% acrylonitrile content, 95% of saturation and 30±5 Mooney viscosity), ZN35253 (34±1.5% acrylonitrile content, 90% saturation and 30±5 Mooney viscosity) and ZN43254 (43±1.5% acrylonitrile content, 90% saturation and 40±5 Mooney viscosity) are characteristic grades of Zhanber HNBR with better mech. property.In the present work, it carried out the contrast experiments on Zhanber HNBR in comparison with other Therben and Zetpol HNBR rubbers according to the same standard compounding formula and comparatively studied on their process performance, mech., heat aging resistance, oil resistance and low temperature resistance properties.In addition, it performed some application R&D on Zhanber HNBR for auto synchronous belt, seals and oilfield rubber products.In conclusion, the Zhanber HNBR has excellent phys. properties and no significant difference on processing performance, phys. and mech. properties with other well-known Therben and Zetpol HNBR products, and Zhanber HNBR can be broadly used for the synchronous belt, seals and other rubber products.Finally, the Zhanber HNBR with low Mooney viscosity can not only improve the phys. and mech. properties of vulcanized rubber, but also improve the processing performance of compounds, which provides rubber industry with more choices in different kinds of applications.

Development of new non-toxic HCV inhibitors with high efficacy and good PK

Author: Zhan, Zheng-Yun J.

Hepatitis C virus (HCV) is a single-stranded pos. RNA virus in the Flaviviridae family, which includes several non-structural proteins (NS1, NS2, NS3, NS4a, NS5a, and NS5b).The NS3 protein possesses serine protease activity and is considered essential for viral replication and infectivity.So far, there is about 3-5% of population infected with HCV worldwide.This presentation discloses the toxicity and PK results of some highly potent HCV inhibitors with new macropolycyclic based structure.Currently, several novel macropolycyclic HCV inhibitors have been determined to show not only very potent (IC₅₀ and EC₅₀ for Ia, Ib, and IIa of NS3-NS4A: 0.1nM-10.0nM) but also non-toxic and competitive or better PK results in comparison with other reported HCV inhibitors such as ITMN-191 (R-7227) and MK-7009 in clin. Phase-II.Furthermore, preclin. study is ongoing and looking forward to discover 2-3 highly competitive HCV inhibitors for further clin. trial.

Development of RCM catalysts excellent for ring-closing synthesis of macrocyclic HCV inhibitors

Author: Zhan, Zheng-Yun J. ; Cheng, Fei ; Pan, Wanlong

Metathesis reaction has been broadly used in discovery and development of new drugs and functional polymer materials.So far, Zhan has reported different kinds of metathesis catalysts for manufacturing of highly quality of polymer products, polydicyclopentadiene (PDCPD) and hydrogenated nitrile butadiene rubber (HNBR).As the progress of new macrocyclic HCV inhibitors is significantly moving forward, the ring-closing metathesis (RCM) catalysts have been broadly studied and used for synthesis of different kinds of macrocyclic-core based HCV inhibitors.In this presentation, a series of new metathesis catalysts have been prepared and used to study the activity and selectivity of RCM reactions, and several RCM catalysts have been developed highly active and selective for synthesis of macrocyclic based HCV inhibitors, which provides a more efficient method for manufacturing of 14-22 membered macrocyclic HCV inhibitors.

100 Deals associated with Shanghai Zannan Technology Co., Ltd.

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100 Translational Medicine associated with Shanghai Zannan Technology Co., Ltd.

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Pipeline

Pipeline Snapshot as of 05 Oct 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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