Delving into the Latest Updates on Liaoning Nuokang Bio-Pharmaceutical Co. Ltd. with Synapse

Overview

Basic Info

Introduction

Grand Life Science (Liaoning) Co., Ltd., a wholly-owned subsidiary of Beijing Yuanda Biotechnology Group Co., Ltd., is a full-value chain pharmaceutical enterprise integrating R&D, production and marketing. The company focuses on the fields of hemostasis, anesthesia, analgesia and wound management. It has a number of listed products such as collagenase for injection of national first-class new drugs and collagenase ointment of domestic exclusive varieties. Hemostasis products represented by hemagglutinin for injection have been in a leading position in China for many years in a row. The company has an independently operated pharmaceutical sales company, research and development center, comprehensive modern production base, API production base and overseas raw material supply base.

Tags

Urogenital Diseases

Skin and Musculoskeletal Diseases

Other Diseases

Small molecule drug

Enzyme

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	4
Enzyme	1

Top 5 Target	Count

D1 receptor(Dopamine D1 receptor)	1
Collagenase	1

Primary objective: To evaluate the ocular and systemic safety and tolerability of single and multiple 7-day ocular administration of DA001 eye drops in healthy subjects. Secondary objective: To evaluate the ocular and systemic pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of single and multiple 7-day ocular administration of DA001 eye drops in healthy subjects.

Start Date08 Dec 2023

Sponsor / Collaborator

Wuhan Daan Pharmacy Co. Ltd.

CTR20232965 / CompletedPhase 1

一项在健康女性受试者中评价马来酸甲麦角新碱注射液药代动力学特征及安全性的开放、单中心临床试验

[Translation] An open, single-center clinical trial to evaluate the pharmacokinetic characteristics and safety of methylergonovine maleate injection in healthy female subjects

主要目的：评价健康女性受试者单次肌肉注射马来酸甲麦角新碱注射液后的药代动力学特征。次要目的：观察健康女性受试者单次肌肉注射马来酸甲麦角新碱注射液后的安全性。

[Translation]

Primary objective: To evaluate the pharmacokinetic characteristics of methylergonovine maleate injection after a single intramuscular injection in healthy female subjects. Secondary objective: To observe the safety of methylergonovine maleate injection after a single intramuscular injection in healthy female subjects.

Start Date09 Oct 2023

Sponsor / Collaborator

Wuhan Daan Pharmacy Co. Ltd.

CTR20230053 / CompletedPhase 1

一项在健康受试者中评价缩宫素甲麦注射液安全性、耐受性及药代动力学特征的随机、开放、单中心临床研究

[Translation] A randomized, open, single-center clinical study to evaluate the safety, tolerability and pharmacokinetic characteristics of oxytocin methylmel injection in healthy subjects

主要目的：评价健康受试者单次肌肉注射缩宫素甲麦注射液后的安全性和耐受性，为该药的II期临床试验提供给药依据。次要目的： 1）评价健康受试者单次肌肉注射缩宫素甲麦注射液后药代动力学特征； 2）对比健康受试者单次肌肉注射缩宫素甲麦注射液和缩宫素注射液的药代动力学特征。

[Translation]

Main purpose: To evaluate the safety and tolerability of single intramuscular injection of oxytocin methylprednisolone injection in healthy subjects, and to provide a basis for dosing for the Phase II clinical trial of the drug. Secondary purpose: 1) To evaluate the pharmacokinetic characteristics of single intramuscular injection of oxytocin methylprednisolone injection in healthy subjects; 2) To compare the pharmacokinetic characteristics of single intramuscular injection of oxytocin methylprednisolone injection and oxytocin injection in healthy subjects.

Start Date06 Feb 2023

Sponsor / Collaborator

Wuhan Daan Pharmacy Co. Ltd.

[+1]

100 Clinical Results associated with Liaoning Nuokang Bio-Pharmaceutical Co. Ltd.

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0 Patents (Medical) associated with Liaoning Nuokang Bio-Pharmaceutical Co. Ltd.

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2

Literatures (Medical) associated with Liaoning Nuokang Bio-Pharmaceutical Co. Ltd.

01 Oct 2022·Bioorganic Chemistry

Discovery of a novel class of benzoxazole derivatives as histamine H3 receptor ligands for the treatment of neuropathic pain

Article

Author: Huang, Chaonan ; Xue, Yulin ; Huang, Ling ; Zhuang, Tao ; Zhou, Huiling ; Xiao, Xinyi ; Li, Ziying ; Zhu, Mo ; Chen, Yin

To discover effective analgesics, we summarize the synthesis, optimization, and pharmacological anti-nociceptive effects of a novel series of benzoxazole derivatives targeting H₃ receptor (H₃R). The new benzoxazoles were assayed in vitro for histamine H₃R and H₁R binding affinity. The best compound 8d (2-methyl-6-(3-(4-methylpiperazin-1-yl)propoxy)benzo[d]oxazole) exhibited high affinity for H₃R (K_i = 19.7 nM), high selectivity for ten other off-target receptors, and negligible effects on human ether-a-go-go-related gene (hERG, cardiac ion channel). In rodent animals, compound 8d dose-dependently reversed formalin-evoked pain (Phase I, ED₅₀ = 6.0 mg/kg; Phase II, ED₅₀ = 7.8 mg/kg) and CCI-induced neuropathic pain (chronic constriction injury, ED₅₀ = 15.6 mg/kg). Furthermore, compound 8d showed an excellent safety profile in acute toxicity test (LD₅₀ > 2000 mg/kg) with a therapeutic index (TI = LD₅₀/ED₅₀) > 250 and showed a desirable drug-like pharmacokinetic profile. Above characteristics indicate that compound 8d represents a promising candidate analgesic for the treatment of neuropathic pain.

Zhongguo Yiyao Gongye Zazhi

Determination of alprostadil emulsion by HPLC with post-column derivatization

Author: Liu, Hongda ; Xue, Yan ; Xue, Baizhong ; Li, Ping ; Wang, Hongying

A post-derivatization HPLC method was established for the determination of alprostadil emulsion.A C₁₈ column was used with the mobile phase of 6.7 mmol/L phosphate buffer (pH 6.3)-acetonitrile (2:1) at the detection wavelength of 278 nm.Beta-naphthol was used as the internal standard and potassium hydroxide solution was used as the derivatization reagent.The calibration curve was linear in the range of 0.5-10 μg/mL.The average recovery was 99.3% with RSD of 0.53%.

100 Deals associated with Liaoning Nuokang Bio-Pharmaceutical Co. Ltd.

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100 Translational Medicine associated with Liaoning Nuokang Bio-Pharmaceutical Co. Ltd.

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

3

2

Approved

Other

4

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Calcium Citrate	Calcium deficiency More	Approved
Collagenase clostridium histolyticum (LiaoNing Weibang) ( Collagenase )	Intervertebral Disc Displacement More	Approved
DA-001	Myopia More	Phase 1
Methyl-Ergonovine/Oxytocin	Hemorrhage More	Phase 1
Methylergonovine Maleate ( D1 receptor )	-	Phase 1