A review.Inulin and oligofructose are the best- documented prebiotics.By interacting with the gut ecosystem, inulin and oligofructose influence a number of physiol. functions, and the health benefits of these ingredients were demonstrated to extend outside the strict environment of the gut.In fact, much attention has recently been focused on their potential health benefits towards weight management.Several animal studies have shown that inulin and oligofructose are able to modulate the expression (and release) of gastrointestinal hormones involved in appetite regulation, with a concomitant lower body weight and adipose tissue gain.In parallel, since recent research has suggested a role for the gut microflora in energy homeostasis, exptl. data have investigated the potential role of prebiotics in this context.Ingestion of a high-fat diet by mice was associated with changes in the microflora composition (e.g. decreased bifidobacteria), higher circulating LPS levels, and hence, was responsible for inducing an inflammatory state, as well as weight gain.In this model, the addition of oligofructose suppressed most of the metabolic alterations caused by the high-fat diet, and these effects were linked to a restoration of bifidobacteria levels.In humans, effects of prebiotics on appetite and energy intake were shown in healthy volunteers.Oligofructose supplementation resulted in lower daily energy intake together with various influences on appetite ratings.Adolescents receiving oligofructose-enriched inulin (Orafti Synergyl) during 1 yr had a lower body weight and body fat mass, as well as an appropriate body mass index (BMI) compared to the control group.Ultimately, data from a recent study demonstrate the ability of oligofructose supplementation to decrease body weight and energy intake in overweight and obese subjects.All together, these findings highlight exciting perspectives for the use of inulin and oligofructose as functional food ingredients in foods designed for weight management.

Inulin-type fructans

Author: Van Loo, Jan ; Bosscher, Douwina

A review on the occurrence, chem. structure, production, phys. and chem. properties, nutritional properties, and food applications of inulin-type fructans.

Nutrafoods

Oligofructose-enriched inulin: keeping optimal body weight

Author: Bosscher, Douwina ; Van Loo, Jan

A review.Recent evidence shows prebiotic inulin-type fructans are able to modulate blood levels of hormones involved in appetite regulation (e.g. Glucagon-Like Peptide-1 (GLP-1) and ghrelin) which could be linked to reductions in energy (and food) intake, body weight and adipose tissue deposition in animal models.Such effects on appetite and food intake were later confirmed in human intervention studies which showed that dietary supplementation of healthy volunteers with Oligofructose P95 increased satiety, reduced hunger and prospective food consumption leading to a lower daily energy intake.A new study on the long term, provides evidence that such effects beneficially can modulate body weightTeenagers who were supplemented for 1-yr with oligofructose-enriched inulin (herein called Synergy1) were able to maintain appropriate body weight and body mass index (BMI) during their growth phase (consistent with physiol. rise during growth), whereas controls could not and had higher weight gain.The human intervention studies thus demonstrate that intake of inulin-type fructans enhance^s satiety, lower^s energy intake and prevent^s non-ideal body weight gain and excess fat mass in healthy individuals.

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