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Overview

Maintenance of appropriate muscle mass is necessary for good quality of life as skeletal muscles play critical roles in locomotion, metabolic homeostasis, and thermogenesis. Polyamines are essential metabolites that regulate several important cellular functions. In C57BL6 mice who underwent sciatic nerve transection of the hind limb, compensatory muscle hypertrophy is enhanced by the administration of polyamines. However, the action mechanisms of polyamines in muscle hypertrophy remain unclear. Here, we isolated PA YEAST SC-1, a polyamine-rich Saccharomyces cerevisiae, from Baker's yeast. We examined whether PA YEAST SC-1 induces muscle hypertrophy and elucidated the underlying action mechanisms of polyamines and the active ingredients in PA YEAST SC-1 using C2C12 myotubes. PA YEAST SC-1 at 1 mg/mL increased myosin heavy chain expression in C2C12 myotubes. Mechanistically, PA YEAST SC-1 induced the activation of Akt/mechanistic target of rapamycin kinase/p70S6K signaling. Furthermore, PA YEAST SC-1 decreased the expression levels of the ubiquitin ligases, atrogin-1 and muscle RING finger-1, via forkhead box O1 phosphorylation. These findings suggest PA YEAST SC-1 as an effective food ingredient for the treatment of muscle hypertrophy.

24 Apr 2021·Bioscience, Biotechnology, and BiochemistryQ4 · ENGINEERING & TECHNOLOGY

Characterization of ω3 fatty acid desaturases from oomycetes and their application toward eicosapentaenoic acid production in Mortierella alpina

Q4 · ENGINEERING & TECHNOLOGY

Article

Author: Kikukawa, Hiroshi ; Ogawa, Jun ; Sakuradani, Eiji ; Ando, Akinori ; Sakamoto, Takaiku ; Mo, Brian K H ; Okuda, Tomoyo ; Ikemoto, Hiroyuki ; Takemoto, Yuki ; Nakatsuji, Ryohei

ABSTRACTω3 Polyunsaturated fatty acids are currently obtained mainly from fisheries; thus, sustainable alternative sources such as oleaginous microorganisms are required. Here, we describe the isolation, characterization, and application of 3 novel ω3 desaturases with ω3 polyunsaturated fatty acid–producing activity at ordinary temperatures (28 °C). First, we selected Pythium sulcatum and Plectospira myriandra after screening for oomycetes with high eicosapentaenoic acid/arachidonic acid ratios and isolated the genes psulω3 and pmd17, respectively, which encode ω3 desaturases. Subsequent characterization showed that PSULω3 exhibited ω3 desaturase activity on both C18 and C20 ω6 polyunsaturated fatty acids while PMD17 exhibited ω3 desaturase activity exclusively on C20 ω6 polyunsaturated fatty acids. Expression of psulω3 and pmd17 in the arachidonic acid–producer Mortierella alpina resulted in transformants that produced eicosapentaenoic acid/total fatty acid values of 38% and 40%, respectively, at ordinary temperatures. These ω3 desaturases should facilitate the construction of sustainable ω3 polyunsaturated fatty acid sources.

01 Dec 2020·Food Science and BiotechnologyQ3 · AGRICULTURAL & FORESTRY SCIENCE

Effects of onion extract containing concentrated cysteine sulfoxides on sleep quality: a randomized, double-blind, placebo-controlled, crossover study

Q3 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Makita, Miki ; Kikuchi, Yosuke ; Nakayama, Yuya ; Nozaki, Satomi

The objective of this randomized, double-blind, placebo-controlled, crossover study was to examine the effects of onion extract containing concentrated cysteine sulfoxides on improving sleep quality. In total, 30 healthy men and women who were dissatisfied with their sleep consumed the test food sample (onion extract tablets) for 5 days. The delta power during non-rapid eye movement sleep and the delta power per minute in the first sleep cycle increased significantly with the intake of onion extract containing concentrated cysteine sulfoxides compared with the intake of placebo. A significant decline in sleep latency was also observed. Salivary α-amylase level, a stress indicator, decreased significantly with the intake of onion extract containing concentrated cysteine sulfoxides compared with the intake of placebo. These findings indicate that onion extract containing concentrated cysteine sulfoxides alleviates stress, improves the quality of sleep and promotes smooth transition into sleep.

100 Deals associated with Nisshin Pharma, Inc.

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100 Translational Medicine associated with Nisshin Pharma, Inc.

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Pipeline

Pipeline Snapshot as of 16 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

N-1197 ( Sodium channels )	Hypertension More	Discontinued
N-1518 ( α-adrenergic receptor x β-adrenoceptors )	Hypertension More	Discontinued
L-623	Neoplasms More	Discontinued
N-3601 ( Phosphoric diester hydrolases x Potassium channel x VDCCs )	Arrhythmias, Cardiac More	Discontinued
N-5984 ( β3-adrenergic receptor )	Urinary Bladder, Overactive More	Discontinued