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Last update 08 May 2025

Rappaport Family Institute for Research in the Medical Science

Private Company|1982|Israel|

www.rappaport.org.il

Private Company|1982|Israel|

www.rappaport.org.il

Last update 08 May 2025

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Translational Medicine

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100 Clinical Results associated with Rappaport Family Institute for Research in the Medical Science

0 Patents (Medical) associated with Rappaport Family Institute for Research in the Medical Science

198

Literatures (Medical) associated with Rappaport Family Institute for Research in the Medical Science

25 Apr 2023·eLife

Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function.

Article

Author: Savir, Yonatan ; Aknin, Eliel ; Wasserman, Tanya ; Ben Yaakov, Tal

The immune system plays a major role in maintaining many physiological processes in the reproductive system. However, a complete characterization of the immune milieu in the ovary, and particularly how it is affected by female aging, is still lacking. Here, we utilize single-cell RNA sequencing and flow cytometry to construct the complete description of the murine ovarian immune system. We show that the composition of the immune cells undergoes an extensive shift with age towards adaptive immunity. We analyze the effect of aging on gene expression and chemokine and cytokine networks and show an overall decreased expression of inflammatory mediators together with an increased expression of senescent cells recognition receptors. Our results suggest that the fertile female's ovarian immune aging differs from the suggested female post-menopause inflammaging as it copes with the inflammatory stimulations during repeated cycles and the increasing need for clearance of accumulating atretic follicles.

01 Jan 2020·In VivoQ4 · MEDICINE

18-kDa Translocator Protein Ligands Protect H9C2 Cardiomyocytes from Cigarette Smoke-induced Cell Death: In Vitro Study

Q4 · MEDICINE

Article

Author: Weizman, Abraham ; Zeineh, Nidal ; Yassin, Nasra ; Gavish, Moshe ; Nagler, Rafael ; Azrad, Maya

BACKGROUNDCigarette smoke (CS) can induce cellular damage via alterations in 18 kDa translocator protein (TSPO)-related functions, leading to cardiovascular diseases. The current study focused on the possible protective effect of TSPO ligands against CS-induced damage to cardiac cells.MATERIALS AND METHODSH9C2 Cardiomyocyte cell line of rat origin was pre-treated with TSPO ligands. Cell death, TSPO binding, and TSPO protein expression levels were assessed following 30-min CS exposure with/without TSPO ligands.RESULTSCS exposure of H9C2 cells significantly incensed cell death (by 26%, p<0.001). Pre-treatment with TSPO ligands at two concentrations prevented cell death. Neither CS nor ligands affected TSPO protein expression in H9C2 cells. CS led to increased cell death and reduced TSPO binding.CONCLUSIONReduced TSPO binding may have a role in CS-induced cell death, and TSPO ligand MGV-1 can prevent suppression of TSPO binding and corresponding cell death. These results may be relevant to treatment of cardiovascular diseases associated with CS.

01 Sep 2019·Journal of Cranio-Maxillofacial SurgeryQ3 · MEDICINE

Non-primary salivary malignancies: A 22-year retrospective study

Q3 · MEDICINE

Article

Author: Rachmiel, Adi ; Israel, Yair ; Gourevich, Konstantin ; Nagler, Rafael

PURPOSEMost salivary gland malignancies are primary tumors, but in our medical center one of six is non-primary. The relative scarcity of such reports justifies studying them.SUBJECTS & METHODSWe studied patients' demographic and clinical parameters, salivary tumors/metastasis, diagnosis and treatment, and survival rates.RESULTSOf all our salivary malignancy patients over the last 22 years, 15% (18/119) had non-primary malignant tumors, all located in the parotid glands. Of these, nine had skin cancer (SCC), 3 malignant solid tumors and 6 hematological systemic malignancies. Four had concomitant second malignancy. Mean age was 70.2 ± 13.8 years, 66.7% of the patients were males, 27.8% were smokers, none reported alcohol use. The most prevalent diagnostic tools used were CT (16 patients), FNA (13) and PET-CT (12). Eleven of 18 patients died from the disease despite receiving therapy: 6 SCC patients, 2 CLL patients and all 3 with solid tumors. All four lymphoma patients survived as did another three SCC patients.CONCLUSIONSChemotherapy and radiotherapy for systemic disease prolonged life rather than surgery. Patients with poor prognosis non-primary salivary tumors should be treated conservatively; surgery should be for those without widespread metastases or systemic disease. Sometimes a palliative patient may benefit from tumor debulking.

100 Deals associated with Rappaport Family Institute for Research in the Medical Science

100 Translational Medicine associated with Rappaport Family Institute for Research in the Medical Science

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Rappaport Family Institute for Research in the Medical Science

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