Delving into the Latest Updates on Piolax Medical Devices, Inc. with Synapse

Overview

PURPOSEThe aim of this study was to develop and assess a novel implantable, wireless-powered, light-emitting diode (LED) for near-infrared photoimmunotherapy (NIR-PIT). NIR-PIT is a recently developed cancer therapy that uses NIR light and antibody-photosensitizer conjugates and is able to induce cancer-specific cell death. Due to limited light penetration depth it is currently unable to treat tumors in deep tissues. Use of implanted LED might potentially overcome this limitation.RESULTSThe wireless LED system was able to emit NIR light up to a distance of 20 cm from the transmitter coil by using low magnetic fields as compliant with limits for use in humans. Results indicated that the LED system was able to kill tumor cells in vitro and to suppress tumor growth in implanted tumor-bearing mice.CONCLUSIONSResults indicated that the proposed implantable wireless LED system was able to suppress tumor growth in vivo. These results are encouraging as wireless LED systems such as the one here developed might be a possible solution to treat tumors in deep regions in humans. Further research in this area would be important.MATERIALS AND METHODSAn implantable LED system was developed. It consisted of a LED capsule including two LED sources and a receiver coil coupled with an external coil and power source. Wireless power transmission was guaranteed by using electromagnetic induction. The system was tested in vitro by using EGFR-expressing cells and HER2-expressing cells. The system was also tested in vivo in tumor-bearing mice.

01 Dec 2013·Gastrointestinal EndoscopyQ1 · MEDICINE

A novel basket catheter to facilitate endoscopic removal of pancreatic stones (with video)

Q1 · MEDICINE

Article

Author: Sasaki, Takashi ; Kogure, Hirofumi ; Koike, Kazuhiko ; Tokyokawa, Yoshihide ; Hirano, Kenji ; Yamamoto, Natsuyo ; Sase, Risa ; Tada, Minoru ; Mizuno, Suguru ; Isayama, Hiroyuki ; Sasahira, Naoki ; Nakai, Yousuke

BACKGROUNDEndoscopic removal of pancreatic stones in patients with chronic pancreatitis is still challenging. With a conventional basket catheter, introduction to the target area or catching pancreatic stones is sometimes difficult.OBJECTIVETo evaluate a novel double-lumen basket catheter composed of nitinol wires with fine reticular structures in the distal end and loose mesh in the proximal part.DESIGNA prospective feasibility study.SETTINGTertiary-care center.PATIENTSThis study involved 10 patients with main pancreatic duct stones of 5 mm or less in the shorter diameter of the largest stone.INTERVENTIONIn the first 5 cases, a nitinol basket catheter was used as salvage after stone extraction with a conventional basket catheter and retrieval balloon (salvage group). In the following 5 cases, stones were initially removed by using a nitinol basket catheter, and the presence of residual stones was evaluated by pancreatogram along with balloon sweep (initial group).MAIN OUTCOME MEASUREMENTSSuccess rate of removal of the target stones and procedure-related adverse events.RESULTSA nitinol basket catheter was easily introduced to the target stone in all patients. In the salvage group, additional stones were retrieved with a nitinol basket catheter in 3 of 5 patients. In the initial group, stone extraction by a nitinol basket catheter was successful, and no residual stones were extracted by additional balloon cleaning in any patients. Basket impaction or after-ERCP pancreatitis was not observed.LIMITATIONSA small sample size without a control group.CONCLUSIONThis novel nitinol basket catheter is useful for the extraction of small pancreatic stones. A randomized, controlled trial is warranted to confirm its efficacy.

Medical applications of superelastic nickel-titanium (Ni-Ti) alloys

Author: Ohkata, I.

A review.This chapter introduces the medical treatment devices that use Ni-Ti shape memory alloys.The superelastic effect of Ni-Ti medical devices has contributed to new clin. techniques (such as orthodontic surgery and minimally invasive treatment) as well as to the improvement of clin. performance.

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