American College of Prosthodontists Education Foundation

This study seeks to test the recently discovered anti-inflammatory action of statins on inflamed mucosa surrounding dental implants.
Hypothesis: The application of 1.2% simvastatin gel will decrease peri-implant inflammation.
The pilot study will involve 44 subjects divided into a test and control group. The test group shall receive topical simvastatin gel administered around the implant with a blunt tipped needle. The control group will receive a placebo.
Inflammatory state shall be determined at baseline as well as follow up visits at 24 hours, 1 week, and 1 month by clinical indices of inflammation as well as biochemical markers of inflammation gathered from around the implants.