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A review with 23 referencesThis article reviews recent patents (1996-1999) which have disclosed novel strategies for targeted cancer therapy and which have cited the enzyme carboxypeptidase G₂ (CPG₂) as a preferred component.Although the described procedures share the common goal of selectively targeting CPG₂ to cancer sites so that it can be used to act catalytically on a sep. administered substance, a number of different methods have been employed to achieve this aim.These include the use of polymers and antibodies as targeting vectors, the use of vectors encoding the enzyme for intra- or extracellular expression and the use of a small-mol. enzyme inhibitor.The methodol. and scope of each invention is described and their advantages and disadvantages discussed within the context of the relevant scientific literature.

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