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Overview

A review with 23 references Determination of the crystal structures of complexes of herpes simplex virus type 1 thymidine kinase (HSV1 TK) with its substrates has provided a detailed picture of the active site and an understanding of the wide substrate range of the enzyme.The binding mode of a class of nonsubstrate inhibitors, exemplified by 9-(4-hydroxybutyl)-N²-phenylguanine (HBPG), has been revealed in the crystal structure of the TK:HBPG complex, allowing rational design of improved inhibitors.Further studies of the effect of HBPG in a murine model of HSV1 latency demonstrated the promise of TK inhibitors in preventing reactivation of herpetic diseases.

Current Opinion in Anti-Infective Investigational Drugs

DNA polymerase III: a new target for antibiotic development

Author: Brown, Neal C. ; Wright, George E.

A review with 15 referencesThere is a rapidly growing crisis in the management of life-threatening disease caused by multi-antibiotic-resistant bacteria.One approach to this problem is the identification of new antibiotic targets and the development of target-selective bullets.A promising unexploited target, the bacterial DNA polymerase III (pol III) is discussed in this review.

100 Deals associated with GL Synthesis, Inc.

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100 Translational Medicine associated with GL Synthesis, Inc.

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