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Last update 08 May 2025

Hailir Pesticides & Chemicals Group Co., Ltd.

Public Company|1999|Shandong Sheng, China|

1,000-5,000

| SHA: 603639|

www.hailir.cn

Public Company|1999|Shandong Sheng, China|

1,000-5,000

| SHA: 603639|

www.hailir.cn

Last update 08 May 2025

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Deal

Translational Medicine

Overview

100 Clinical Results associated with Hailir Pesticides & Chemicals Group Co., Ltd.

0 Patents (Medical) associated with Hailir Pesticides & Chemicals Group Co., Ltd.

Literatures (Medical) associated with Hailir Pesticides & Chemicals Group Co., Ltd.

01 Apr 2025·International Journal of Biological Macromolecules

A simple approach to fabricate chitosan-delivered avermectin controlled release microparticles for improved efficacy and reduced residues

Article

Author: Zhao, Pengyue ; Kong, Xiang-Ping ; Ge, Jia-Cheng ; Li, Weina ; Luo, Lan ; Wang, Juan ; Liu, Jun-Hao ; Li, Wei-Kun ; Jiang, Shoulin

The presence of a synergistic effect between carrier and insecticide in controlled release formulations is highly desirable to improve efficacy to target pests and reduce insecticide use. Herein, controlled release microparticles of avermectin (AVM) were fabricated using natural chitosan (CTS) as a carrier by a pH adjustment method. The resulted AVM@CTS microparticles displayed high encapsulation efficiency (73.3 %), outstanding photostability, obvious pH/temperature sensitivity, and good deposition behavior on Chinese cabbage leaves. Instrument detections in combination with molecular dynamics simulations showed that AVM interacted with CTS mainly through physical adsorption, adhesion, and weak H-bonds. In vitro release data of the controlled release formulation obeyed the first-order kinetic equation. Toxicity tests exhibited a significantly synergistic effect between CTS and AVM, resulting in better quick-acting and long-term efficacy against Plutella xylostella larvae than that of the AVM acetone solution. The 72 h LC₅₀ of the formulation for a 21-day efficacy was 12.73 mg/L, much lower than the value (31.53 mg/L) of the AVM solution. Moreover, the AVM@CTS microparticles exhibited shorter half-life (19.6 days) than the unformulated AVM (23.0 days) under natural conditions in soil. This work contributes to the development of controlled release system with carrier-insecticide synergistic effect for sustainable pest control.

16 Dec 2024·ACS Agricultural Science & Technology

Residue Dissipation Dynamics and Dietary Risk Assessment of Kasugamycin, Oxine-Copper, Dimethomorph, and Pyraclostrobin in Cucumber

Author: Jiang, Xinyue ; Li, Beixing ; Liu, Yujuan ; Qin, Yingying ; Bai, Haixiu ; Han, Wen-xing ; Mu, Wei ; Bu, Fanxin ; Wang, Kai ; Zou, Nan ; Meng, Lingtao

In recent years, pesticides have been overapplied to prevent and control cucumber diseases, and high pesticide residues on cucumbers have become a growing concern.Therefore, the establishment of a rapid and reliable method for the detection of pesticide residues is particularly required to ensure the health of humans and livestock.This study optimized the determination method of pesticide residues in cucumber using a QuEchERS pretreatment combined with an ultrahigh performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS).The optimized method achieved a spike recovery rate of 79.1-103.3% for the kasugamycin, oxine-copper, dimethomorph, and pyraclostrobin in cucumber, and the limit of quantification (LOQ) was 0.01 mg/kg.The optimized method was used to detect there residues in 12 regions.The dissipation half-lives of oxine-copper, dimethomorph, and pyraclostrobin were 1.64-2.19 d, 1.15 d, and 1.20-1.27 d, resp.The final residue levels of these pesticides were all below the maximum residue limit (MRL).The dietary risk assessment showed that the daily intake of kasugamycin, oxine-copper, dimethomorph, and pyraclostrobin accounted for 0.7%, 35.7%, 23.7%, and 20.5% of the daily allowable intake, resp., which were all within acceptable ranges.This indicates that under the ecol. conditions in China, these pesticides are safe under good agricultural practices (GAP).This study provides guidance for the comprehensive evaluation and scientific use of fungicide residues in the cultivation of vegetables cash crops such as cucumber.

01 Oct 2023·Pest management science

Coprecipitation-based synchronous chlorantraniliprole encapsulation with chitosan: carrier-pesticide interactions and release behavior.

Article

Author: Liu, Jun-Hao ; Wang, Juan ; Li, Ding-Li ; Ge, Jia-Cheng ; Kong, Xiang-Ping ; Yu, Shu-Lan ; Wang, Meng ; Li, Hongchun ; Li, Weina ; Han, Xian-Zheng

BACKGROUNDControlled-release pesticide formulations have emerged as a promising approach towards sustainable pest control. Herein, an environment-friendly formulation of insecticide chlorantraniliprole (CAP) was fabricated through a simple approach of coprecipitation-based synchronous encapsulation by chitosan (CTS), with carrier-pesticide interaction mechanism and release behavior investigated.RESULTSThe resulting CAP/CTS controlled-release formulation (CCF) showed a good loading content of 28.1% and a high encapsulation efficiency of 75.6%. Instrument determination in combination with molecular dynamics (MD) simulations displayed that the primary interactions between CAP and CTS were physical adsorption and complicated hydrogen (H)-bonds, which formed dominantly between NH in amides [or nitrogen (N) in ring structures] of CAP and hydroxyl (or amino) groups of CTS, as well as oxygen (O) in CAP with hydrogen in CTS or H₂ O molecules. The in vitro release tests exhibited obvious pH/temperature sensitivity, with release dynamics following the first-order or Ritger-Peppas model. As the temperature increased, the CAP release process of the Ritger-Peppas model changed from Case-II to anomalous transport, and ultimately to a Fickian diffusion mechanism. The control effect against Plutella xylostella larvae also was evaluated by toxicity tests, where comparable efficacy of CCF to the commercial suspension concentrate was obtained.CONCLUSIONThe innovative, easy-to-prepare CCF can be used as a formulation with obvious pH/temperature sensitivity and good efficacy on target pests. This work contributes to the development of efficient and safe pesticide delivery systems, especially using the natural polymer materials as carriers. © 2023 Society of Chemical Industry.

100 Deals associated with Hailir Pesticides & Chemicals Group Co., Ltd.

100 Translational Medicine associated with Hailir Pesticides & Chemicals Group Co., Ltd.

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Hailir Pesticides & Chemicals Group Co., Ltd.

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